The authors have used a series of elegant biochemical and cell biology approaches to demonstrate that the myocyte developmental program is under the control of a class II histone deacetylase. Calcium-induced signals modulate the interaction of class II HDACs with MEF transcription factors in muscle-specific promoters, resulting in the activation of muscle differentiation.
|Original language||English (US)|
|Number of pages||7|
|Publication status||Published - 2001|
ASJC Scopus subject areas
- Molecular Medicine