Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

S. Thébault, E. Verdin, J. Lu, T. A. McKinsey, C. L. Zhang, N. E. Olson

Research output: Contribution to journalArticle

Abstract

The authors have used a series of elegant biochemical and cell biology approaches to demonstrate that the myocyte developmental program is under the control of a class II histone deacetylase. Calcium-induced signals modulate the interaction of class II HDACs with MEF transcription factors in muscle-specific promoters, resulting in the activation of muscle differentiation.

Original languageEnglish (US)
Pages (from-to)720-726
Number of pages7
JournalChemtracts
Volume14
Issue number13
StatePublished - 2001

Fingerprint

MEF2 Transcription Factors
Histone Deacetylases
Muscle Development
Muscle
Association reactions
Cytology
Muscles
Muscle Cells
Cell Biology
Transcription Factors
Chemical activation
Calcium

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. / Thébault, S.; Verdin, E.; Lu, J.; McKinsey, T. A.; Zhang, C. L.; Olson, N. E.

In: Chemtracts, Vol. 14, No. 13, 2001, p. 720-726.

Research output: Contribution to journalArticle

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