Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

S. Thébault, E. Verdin, J. Lu, T. A. McKinsey, C. L. Zhang, N. E. Olson

Research output: Contribution to journalReview article


The authors have used a series of elegant biochemical and cell biology approaches to demonstrate that the myocyte developmental program is under the control of a class II histone deacetylase. Calcium-induced signals modulate the interaction of class II HDACs with MEF transcription factors in muscle-specific promoters, resulting in the activation of muscle differentiation.

Original languageEnglish (US)
Pages (from-to)720-726
Number of pages7
Issue number13
StatePublished - Dec 1 2001


ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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