Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

S. Thébault, E. Verdin, J. Lu, T. A. McKinsey, C. L. Zhang, N. E. Olson

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Abstract

The authors have used a series of elegant biochemical and cell biology approaches to demonstrate that the myocyte developmental program is under the control of a class II histone deacetylase. Calcium-induced signals modulate the interaction of class II HDACs with MEF transcription factors in muscle-specific promoters, resulting in the activation of muscle differentiation.

Original languageEnglish (US)
Pages (from-to)720-726
Number of pages7
JournalChemtracts
Volume14
Issue number13
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Molecular Medicine

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