Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins

John M. Andersen, John M. Dietschy

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

In the intact rat the rate of sterol synthesis in the adrenal gland is normally suppressed to very low levels. However, following inhibition of hepatic lipoprotein production by administration of 4-aminopyrazolopyrimidine to the animals the mean serum cholesterol level decreased from 53 to 6 mg·dl-1, and, coincident with this change, the rate of adrenal sterol synthesis increased 51 fold. The infusion of purified high and low density lipoprotein fractions from the plasma of man inhibited sterol synthesis in such derepressed adrenal glands in proportion to the amount of cholesterol infused into the animal in each of these fractions. At any given plasma cholesterol level, however, the degree of inhibition was significantly greater following the infusion of HDL than after administration of LDL.

Original languageEnglish (US)
Pages (from-to)880-885
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume72
Issue number3
DOIs
StatePublished - Oct 4 1976

Keywords

  • 4-aminopyrazolopyrimidine
  • ACTH
  • APP
  • DPS
  • HDL
  • HMG CoA reductase
  • LDL
  • adrenocorticotropic hormone
  • digitonin precipitable sterols
  • high density lipoproteins
  • low density lipoproteins
  • β-hydroxy-β-methylglutaryl Co-Enzyme A reductase (E.C. 1.1.1.34)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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