Abstract
The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ≫ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.
Original language | English (US) |
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Pages (from-to) | 330-334 |
Number of pages | 5 |
Journal | Seminars in Arthritis and Rheumatism |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - Apr 1992 |
Keywords
- ICAM-1
- Synovial membrane
- cell-adhesion molecules
- cytokine
- rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
- Anesthesiology and Pain Medicine