Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000

S. M. Gilboa, P. Mendola, A. F. Olshan, P. H. Langlois, D. A. Savitz, D. Loomis, A. H. Herring, David E Fixler

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 μm in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status, and maternal county of residence at delivery. Stationary monitoring data were used to estimate air pollution exposure. Logistic regression models adjusted for covariates available in the vital record. When the highest quartile of exposure was compared with the lowest, the authors observed positive associations between carbon monoxide and tetralogy of Fallot (odds ratio = 2.04, 95% confidence interval: 1.26, 3.29), particulate matter <10 μm in aerodynamic diameter and isolated atrial septal defects (odds ratio = 2.27, 95% confidence interval: 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95% confidence interval: 1.51, 3.09). There were inverse associations between carbon monoxide and isolated atrial septal defects and between ozone and isolated ventricular septal defects. Evidence that air pollution exposure influences the risk of oral clefts was limited. Suggestive results support a previously reported finding of an association between ozone exposure and pulmonary artery and valve defects.

Original languageEnglish (US)
Pages (from-to)238-252
Number of pages15
JournalAmerican Journal of Epidemiology
Volume162
Issue number3
DOIs
StatePublished - Aug 2005

Fingerprint

Ozone
Carbon Monoxide
Sulfur Dioxide
Particulate Matter
Atrial Heart Septal Defects
Ventricular Heart Septal Defects
Odds Ratio
Air
Air Pollution
Confidence Intervals
Logistic Models
Maternal Exposure
Nitrogen Dioxide
Pulmonary Valve
Air Pollutants
Fetal Death
Tetralogy of Fallot
Pulmonary Artery
Case-Control Studies
Mothers

Keywords

  • Abnormalities
  • Air pollution
  • Cleft lip
  • Cleft palate
  • Environment and public health
  • Heart defects, congenital

ASJC Scopus subject areas

  • Epidemiology

Cite this

Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000. / Gilboa, S. M.; Mendola, P.; Olshan, A. F.; Langlois, P. H.; Savitz, D. A.; Loomis, D.; Herring, A. H.; Fixler, David E.

In: American Journal of Epidemiology, Vol. 162, No. 3, 08.2005, p. 238-252.

Research output: Contribution to journalArticle

Gilboa, SM, Mendola, P, Olshan, AF, Langlois, PH, Savitz, DA, Loomis, D, Herring, AH & Fixler, DE 2005, 'Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000', American Journal of Epidemiology, vol. 162, no. 3, pp. 238-252. https://doi.org/10.1093/aje/kwi189
Gilboa, S. M. ; Mendola, P. ; Olshan, A. F. ; Langlois, P. H. ; Savitz, D. A. ; Loomis, D. ; Herring, A. H. ; Fixler, David E. / Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000. In: American Journal of Epidemiology. 2005 ; Vol. 162, No. 3. pp. 238-252.
@article{a801a0002ac8431988f739f21c0f10c9,
title = "Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000",
abstract = "A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 μm in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status, and maternal county of residence at delivery. Stationary monitoring data were used to estimate air pollution exposure. Logistic regression models adjusted for covariates available in the vital record. When the highest quartile of exposure was compared with the lowest, the authors observed positive associations between carbon monoxide and tetralogy of Fallot (odds ratio = 2.04, 95{\%} confidence interval: 1.26, 3.29), particulate matter <10 μm in aerodynamic diameter and isolated atrial septal defects (odds ratio = 2.27, 95{\%} confidence interval: 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95{\%} confidence interval: 1.51, 3.09). There were inverse associations between carbon monoxide and isolated atrial septal defects and between ozone and isolated ventricular septal defects. Evidence that air pollution exposure influences the risk of oral clefts was limited. Suggestive results support a previously reported finding of an association between ozone exposure and pulmonary artery and valve defects.",
keywords = "Abnormalities, Air pollution, Cleft lip, Cleft palate, Environment and public health, Heart defects, congenital",
author = "Gilboa, {S. M.} and P. Mendola and Olshan, {A. F.} and Langlois, {P. H.} and Savitz, {D. A.} and D. Loomis and Herring, {A. H.} and Fixler, {David E}",
year = "2005",
month = "8",
doi = "10.1093/aje/kwi189",
language = "English (US)",
volume = "162",
pages = "238--252",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000

AU - Gilboa, S. M.

AU - Mendola, P.

AU - Olshan, A. F.

AU - Langlois, P. H.

AU - Savitz, D. A.

AU - Loomis, D.

AU - Herring, A. H.

AU - Fixler, David E

PY - 2005/8

Y1 - 2005/8

N2 - A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 μm in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status, and maternal county of residence at delivery. Stationary monitoring data were used to estimate air pollution exposure. Logistic regression models adjusted for covariates available in the vital record. When the highest quartile of exposure was compared with the lowest, the authors observed positive associations between carbon monoxide and tetralogy of Fallot (odds ratio = 2.04, 95% confidence interval: 1.26, 3.29), particulate matter <10 μm in aerodynamic diameter and isolated atrial septal defects (odds ratio = 2.27, 95% confidence interval: 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95% confidence interval: 1.51, 3.09). There were inverse associations between carbon monoxide and isolated atrial septal defects and between ozone and isolated ventricular septal defects. Evidence that air pollution exposure influences the risk of oral clefts was limited. Suggestive results support a previously reported finding of an association between ozone exposure and pulmonary artery and valve defects.

AB - A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 μm in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status, and maternal county of residence at delivery. Stationary monitoring data were used to estimate air pollution exposure. Logistic regression models adjusted for covariates available in the vital record. When the highest quartile of exposure was compared with the lowest, the authors observed positive associations between carbon monoxide and tetralogy of Fallot (odds ratio = 2.04, 95% confidence interval: 1.26, 3.29), particulate matter <10 μm in aerodynamic diameter and isolated atrial septal defects (odds ratio = 2.27, 95% confidence interval: 1.43, 3.60), and sulfur dioxide and isolated ventricular septal defects (odds ratio = 2.16, 95% confidence interval: 1.51, 3.09). There were inverse associations between carbon monoxide and isolated atrial septal defects and between ozone and isolated ventricular septal defects. Evidence that air pollution exposure influences the risk of oral clefts was limited. Suggestive results support a previously reported finding of an association between ozone exposure and pulmonary artery and valve defects.

KW - Abnormalities

KW - Air pollution

KW - Cleft lip

KW - Cleft palate

KW - Environment and public health

KW - Heart defects, congenital

UR - http://www.scopus.com/inward/record.url?scp=24144503436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24144503436&partnerID=8YFLogxK

U2 - 10.1093/aje/kwi189

DO - 10.1093/aje/kwi189

M3 - Article

C2 - 15987727

AN - SCOPUS:24144503436

VL - 162

SP - 238

EP - 252

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 3

ER -