Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis

William E. Feldman, Charles M. Ginsburg, George H. McCracken, Dolores Allen, Peter Ahmann, J. Graham, L. Graham

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Forty-four patients with Haemophilus influenzae type b meningitis had follow-up evaluations approximately one year after hospital discharge. Patients with >-107 colony-forming units of H. influenzae type b per milliliters CSF had significantly greater frequencies of speech impairment (P<0.001), hearing loss (P=0.04), and moderate or severe neurologic sequelae (P<0.01). Patients with ≥1 μg H. influenzae b antigen/ml CSF had a greater incidence of hearing loss (P=0.03) but not of speech abnormalities (P=0.06) or other neurologic sequelae (P=0.64). Glucose concentrations <10 mg/dl correlated with the incidence of hearing loss (P=0.02) and speech impairment (P=0.02). "Partial" antibiotic therapy, CSF protein concentrations, and number of CSF polymorphonuclear leukocytes did not correlate well with sequelae. These data indicate that pretreatment concentrations of H. influenzae b and glucose concentrations in CSF were the best predictors of late sequelae of patients with H. influenzae b meningitis.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalThe Journal of Pediatrics
Volume100
Issue number2
DOIs
StatePublished - 1982

Fingerprint

Haemophilus influenzae type b
Meningitis
Cerebrospinal Fluid
Hearing Loss
Nervous System
Glucose
Incidence
Neutrophils
Stem Cells
Anti-Bacterial Agents
Antigens
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis. / Feldman, William E.; Ginsburg, Charles M.; McCracken, George H.; Allen, Dolores; Ahmann, Peter; Graham, J.; Graham, L.

In: The Journal of Pediatrics, Vol. 100, No. 2, 1982, p. 209-212.

Research output: Contribution to journalArticle

@article{9e9bf3cc2f3e471a99ea966583fb3faf,
title = "Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis",
abstract = "Forty-four patients with Haemophilus influenzae type b meningitis had follow-up evaluations approximately one year after hospital discharge. Patients with >-107 colony-forming units of H. influenzae type b per milliliters CSF had significantly greater frequencies of speech impairment (P<0.001), hearing loss (P=0.04), and moderate or severe neurologic sequelae (P<0.01). Patients with ≥1 μg H. influenzae b antigen/ml CSF had a greater incidence of hearing loss (P=0.03) but not of speech abnormalities (P=0.06) or other neurologic sequelae (P=0.64). Glucose concentrations <10 mg/dl correlated with the incidence of hearing loss (P=0.02) and speech impairment (P=0.02). {"}Partial{"} antibiotic therapy, CSF protein concentrations, and number of CSF polymorphonuclear leukocytes did not correlate well with sequelae. These data indicate that pretreatment concentrations of H. influenzae b and glucose concentrations in CSF were the best predictors of late sequelae of patients with H. influenzae b meningitis.",
author = "Feldman, {William E.} and Ginsburg, {Charles M.} and McCracken, {George H.} and Dolores Allen and Peter Ahmann and J. Graham and L. Graham",
year = "1982",
doi = "10.1016/S0022-3476(82)80636-7",
language = "English (US)",
volume = "100",
pages = "209--212",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis

AU - Feldman, William E.

AU - Ginsburg, Charles M.

AU - McCracken, George H.

AU - Allen, Dolores

AU - Ahmann, Peter

AU - Graham, J.

AU - Graham, L.

PY - 1982

Y1 - 1982

N2 - Forty-four patients with Haemophilus influenzae type b meningitis had follow-up evaluations approximately one year after hospital discharge. Patients with >-107 colony-forming units of H. influenzae type b per milliliters CSF had significantly greater frequencies of speech impairment (P<0.001), hearing loss (P=0.04), and moderate or severe neurologic sequelae (P<0.01). Patients with ≥1 μg H. influenzae b antigen/ml CSF had a greater incidence of hearing loss (P=0.03) but not of speech abnormalities (P=0.06) or other neurologic sequelae (P=0.64). Glucose concentrations <10 mg/dl correlated with the incidence of hearing loss (P=0.02) and speech impairment (P=0.02). "Partial" antibiotic therapy, CSF protein concentrations, and number of CSF polymorphonuclear leukocytes did not correlate well with sequelae. These data indicate that pretreatment concentrations of H. influenzae b and glucose concentrations in CSF were the best predictors of late sequelae of patients with H. influenzae b meningitis.

AB - Forty-four patients with Haemophilus influenzae type b meningitis had follow-up evaluations approximately one year after hospital discharge. Patients with >-107 colony-forming units of H. influenzae type b per milliliters CSF had significantly greater frequencies of speech impairment (P<0.001), hearing loss (P=0.04), and moderate or severe neurologic sequelae (P<0.01). Patients with ≥1 μg H. influenzae b antigen/ml CSF had a greater incidence of hearing loss (P=0.03) but not of speech abnormalities (P=0.06) or other neurologic sequelae (P=0.64). Glucose concentrations <10 mg/dl correlated with the incidence of hearing loss (P=0.02) and speech impairment (P=0.02). "Partial" antibiotic therapy, CSF protein concentrations, and number of CSF polymorphonuclear leukocytes did not correlate well with sequelae. These data indicate that pretreatment concentrations of H. influenzae b and glucose concentrations in CSF were the best predictors of late sequelae of patients with H. influenzae b meningitis.

UR - http://www.scopus.com/inward/record.url?scp=0020072681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020072681&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(82)80636-7

DO - 10.1016/S0022-3476(82)80636-7

M3 - Article

C2 - 7057327

AN - SCOPUS:0020072681

VL - 100

SP - 209

EP - 212

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2

ER -