Relationship between biochemical and virological responses to interferon therapy in chronic hepatitis C infection

P. J. Pockros, M. Tong, W. M. Lee, D. J. Van Leeuwen, E. B. Keeffe, K. Bala, P. G. Killenberg, R. T. Foust, H. J. Rosenblate, K. M. Payne, H. Fromm, H. R. Lesesne, M. Black

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have investigated the relationship between serum alanine aminotransferase (ALT) and hepatitis C virus (HCV) RNA in the assessment of responses to interferon (IFN) therapy in chronic HCV infection. Data from 704 patients with HCV infection who were randomized to receive consensus IFN-α (CIFN) 3 μg (n = 232 patients) or 9 μg (n = 232 patients), or IFN-α2b 3 million units (MU) (n = 240 patients), were used for these analyses. All patients were treated three times weekly for 24 weeks and then were observed for a further 24 weeks. Hepatitis C viral RNA (HCV RNA) was determined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) with a lower limit of detection of 100 copies ml-1. Of patients with normal serum ALT concentrations, 53% (120/225) had undetectable HCV RNA at the end-of- treatment period and 47% (51/109) had undetectable HCV RNA at the end of the post-treatment observation period. In contrast, of the patients with undetectable HCV RNA, 75% (120/161) and 84% (51/61) had normal serum ALT activities at the end-of-treatment and post-treatment observations periods, respectively. The majority of patients with undetectable HCV RNA had normal ALT values. In contrast, only half of the patients with normal ALT values were negative for HCV. End-of-treatment HCV RNA response also better predicted sustained virological response than did end-of-treatment ALT response.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalJournal of Viral Hepatitis
Volume5
Issue number4
DOIs
StatePublished - Jul 1998

Fingerprint

Chronic Hepatitis C
Hepacivirus
Interferons
Alanine Transaminase
Infection
RNA
Therapeutics
Virus Diseases
Serum
Viral RNA
Hepatitis C
Reverse Transcriptase Polymerase Chain Reaction
Limit of Detection
Observation

Keywords

  • ALT
  • Clinical study
  • Consensus interferon
  • HCV infection
  • HCV RNA
  • Interferon

ASJC Scopus subject areas

  • Hepatology
  • Virology

Cite this

Relationship between biochemical and virological responses to interferon therapy in chronic hepatitis C infection. / Pockros, P. J.; Tong, M.; Lee, W. M.; Van Leeuwen, D. J.; Keeffe, E. B.; Bala, K.; Killenberg, P. G.; Foust, R. T.; Rosenblate, H. J.; Payne, K. M.; Fromm, H.; Lesesne, H. R.; Black, M.

In: Journal of Viral Hepatitis, Vol. 5, No. 4, 07.1998, p. 271-276.

Research output: Contribution to journalArticle

Pockros, PJ, Tong, M, Lee, WM, Van Leeuwen, DJ, Keeffe, EB, Bala, K, Killenberg, PG, Foust, RT, Rosenblate, HJ, Payne, KM, Fromm, H, Lesesne, HR & Black, M 1998, 'Relationship between biochemical and virological responses to interferon therapy in chronic hepatitis C infection', Journal of Viral Hepatitis, vol. 5, no. 4, pp. 271-276. https://doi.org/10.1046/j.1365-2893.1998.00114.x
Pockros, P. J. ; Tong, M. ; Lee, W. M. ; Van Leeuwen, D. J. ; Keeffe, E. B. ; Bala, K. ; Killenberg, P. G. ; Foust, R. T. ; Rosenblate, H. J. ; Payne, K. M. ; Fromm, H. ; Lesesne, H. R. ; Black, M. / Relationship between biochemical and virological responses to interferon therapy in chronic hepatitis C infection. In: Journal of Viral Hepatitis. 1998 ; Vol. 5, No. 4. pp. 271-276.
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