TY - JOUR
T1 - Relationship between serum uric acid and bone mineral density in the general population and in rats with experimental hyperuricemia
AU - Zhang, Dihua
AU - Bobulescu, I. Alexandru
AU - Maalouf, Naim M.
AU - Adams-Huet, Beverley
AU - Poindexter, John
AU - Park, Sun
AU - Wei, Fuxin
AU - Chen, Christopher
AU - Moe, Orson W.
AU - Sakhaee, Khashayar
N1 - Publisher Copyright:
© 2014 American Society for Bone and Mineral Research. © 2015 American Society for Bone and Mineral Research.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Higher serum uric acid concentrations have been associated with higher bone mineral density (BMD) in observational studies of older men and perimenopausal or postmenopausal women, prompting speculation of a potential protective effect of uric acid on bone. Whether this relationship is present in the general population has not been examined and there is no data to support causality. We conducted a cross-sectional analysis of a probability sample of the U.S. population. Demographic data, dietary intake, lifestyle risk factors and physical activity assessment data, serum biochemistry including serum uric acid, and BMD were obtained from 6759 National Health and Nutrition Examination Survey (NHANES; 2005-2010) participants over 30 years of age. In unadjusted analyses, higher serum uric acid levels were associated with higher BMD at the femoral neck, total hip, and lumbar spine in men, premenopausal women, and postmenopausal women not treated with estrogen. However, these associations were no longer statistically significant after adjustment for potential confounders, including age, body mass index (BMI), black race, alcohol consumption, estimated glomerular filtration rate (eGFR), serum alkaline phosphatase, and C-reactive protein (CRP). This is in contradistinction to some prevailing conclusions in the literature. To further examine the causal effect of higher serum uric acid on skeletal health, including biomechanical properties that are not measurable in humans, we used an established rat model of inducible mild hyperuricemia. There were no differences in BMD, bone volume density, and bone biomechanical properties between hyperuricemic rats and normouricemic control animals. Taken together, our data do not support the hypothesis that higher serum uric acid has protective effects on bone health.
AB - Higher serum uric acid concentrations have been associated with higher bone mineral density (BMD) in observational studies of older men and perimenopausal or postmenopausal women, prompting speculation of a potential protective effect of uric acid on bone. Whether this relationship is present in the general population has not been examined and there is no data to support causality. We conducted a cross-sectional analysis of a probability sample of the U.S. population. Demographic data, dietary intake, lifestyle risk factors and physical activity assessment data, serum biochemistry including serum uric acid, and BMD were obtained from 6759 National Health and Nutrition Examination Survey (NHANES; 2005-2010) participants over 30 years of age. In unadjusted analyses, higher serum uric acid levels were associated with higher BMD at the femoral neck, total hip, and lumbar spine in men, premenopausal women, and postmenopausal women not treated with estrogen. However, these associations were no longer statistically significant after adjustment for potential confounders, including age, body mass index (BMI), black race, alcohol consumption, estimated glomerular filtration rate (eGFR), serum alkaline phosphatase, and C-reactive protein (CRP). This is in contradistinction to some prevailing conclusions in the literature. To further examine the causal effect of higher serum uric acid on skeletal health, including biomechanical properties that are not measurable in humans, we used an established rat model of inducible mild hyperuricemia. There were no differences in BMD, bone volume density, and bone biomechanical properties between hyperuricemic rats and normouricemic control animals. Taken together, our data do not support the hypothesis that higher serum uric acid has protective effects on bone health.
KW - ANALYSIS/QUANTITATION OF BONE
KW - BIOCHEMICAL MARKERS OF BONE TURNOVER
KW - BONE MODELING AND REMODELING
KW - DISEASES AND DISORDERS OF/RELATED TO BONE
KW - DXA
KW - HORMONE REPLACEMENT/RECEPTOR MODULATORS
KW - OSTEOPOROSIS
KW - THERAPEUTICS
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U2 - 10.1002/jbmr.2430
DO - 10.1002/jbmr.2430
M3 - Article
C2 - 25491196
AN - SCOPUS:84929333921
SN - 0884-0431
VL - 30
SP - 1
EP - 8
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 6
ER -