Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis

Shiv Saidha, Elias S. Sotirchos, Jiwon Oh, Stephanie B. Syc, Michaela A. Seigo, Navid Shiee, Chistopher Eckstein, Mary K. Durbin, Jonathan D. Oakley, Scott A. Meyer, Teresa C. Frohman, Scott Newsome, John N. Ratchford, Laura J. Balcer, Dzung L. Pham, Ciprian M. Crainiceanu, Elliot Frohman, Daniel S. Reich, Peter A. Calabresi

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Objective: To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size) and brain substructure volumes in multiple sclerosis (MS). Design: Cross-sectional study. Setting: Johns Hopkins University, Baltimore, Maryland. Participants: A total of 84 patients with MS and 24 healthy control subjects. Main Outcome Measures: High-definition spectraldomain OCT conventional and automated segmentationderived discrete retinal layer thicknesses and 3-T magnetic resonance imaging brain substructure volumes. Results: Peripapillary retinal nerve fiber layer as well as composite ganglion cell layer + inner plexiform layer thicknesses in the eyes of patients with MS without a history of optic neuritis were associated with cortical gray matter (P=.01 and P=.04, respectively) and caudate (P=.04 and P=.03, respectively) volumes. Inner nuclear layer thickness, also in eyes without a history of optic neuritis, was associated with fluid-attenuated inversion recovery lesion volume (P=.007) and inversely associated with normal-appearing white matter volume (P=.005) in relapsing-remitting MS. As intracranial volume was found to be related with several of the OCT measures in patients with MS and healthy control subjects and is already known to be associated with brain substructure volumes, all OCT-brain substructure relationships were adjusted for intracranial volume. Conclusions: Retinal measures reflect global central nervous system pathology in multiple sclerosis, with thicknesses of discrete retinal layers each appearing to be associated with distinct central nervous system processes. Moreover, OCT measures appear to correlate with intracranial volume in patients with MS and healthy control subjects, an important unexpected factor unaccounted for in prior studies examining the relationships between peripapillary retinal nerve fiber layer thickness and brain substructure volumes.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalArchives of Neurology
Volume70
Issue number1
DOIs
StatePublished - Jan 2013

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Optical Coherence Tomography
Multiple Sclerosis
Central Nervous System
Pathology
Brain
Optic Neuritis
Healthy Volunteers
Nerve Fibers
Relapsing-Remitting Multiple Sclerosis
Baltimore
Ganglia
Layer
Cross-Sectional Studies
Head
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Thickness
Tomography
Optical

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis. / Saidha, Shiv; Sotirchos, Elias S.; Oh, Jiwon; Syc, Stephanie B.; Seigo, Michaela A.; Shiee, Navid; Eckstein, Chistopher; Durbin, Mary K.; Oakley, Jonathan D.; Meyer, Scott A.; Frohman, Teresa C.; Newsome, Scott; Ratchford, John N.; Balcer, Laura J.; Pham, Dzung L.; Crainiceanu, Ciprian M.; Frohman, Elliot; Reich, Daniel S.; Calabresi, Peter A.

In: Archives of Neurology, Vol. 70, No. 1, 01.2013, p. 34-43.

Research output: Contribution to journalArticle

Saidha, S, Sotirchos, ES, Oh, J, Syc, SB, Seigo, MA, Shiee, N, Eckstein, C, Durbin, MK, Oakley, JD, Meyer, SA, Frohman, TC, Newsome, S, Ratchford, JN, Balcer, LJ, Pham, DL, Crainiceanu, CM, Frohman, E, Reich, DS & Calabresi, PA 2013, 'Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis', Archives of Neurology, vol. 70, no. 1, pp. 34-43. https://doi.org/10.1001/jamaneurol.2013.573
Saidha, Shiv ; Sotirchos, Elias S. ; Oh, Jiwon ; Syc, Stephanie B. ; Seigo, Michaela A. ; Shiee, Navid ; Eckstein, Chistopher ; Durbin, Mary K. ; Oakley, Jonathan D. ; Meyer, Scott A. ; Frohman, Teresa C. ; Newsome, Scott ; Ratchford, John N. ; Balcer, Laura J. ; Pham, Dzung L. ; Crainiceanu, Ciprian M. ; Frohman, Elliot ; Reich, Daniel S. ; Calabresi, Peter A. / Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis. In: Archives of Neurology. 2013 ; Vol. 70, No. 1. pp. 34-43.
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abstract = "Objective: To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size) and brain substructure volumes in multiple sclerosis (MS). Design: Cross-sectional study. Setting: Johns Hopkins University, Baltimore, Maryland. Participants: A total of 84 patients with MS and 24 healthy control subjects. Main Outcome Measures: High-definition spectraldomain OCT conventional and automated segmentationderived discrete retinal layer thicknesses and 3-T magnetic resonance imaging brain substructure volumes. Results: Peripapillary retinal nerve fiber layer as well as composite ganglion cell layer + inner plexiform layer thicknesses in the eyes of patients with MS without a history of optic neuritis were associated with cortical gray matter (P=.01 and P=.04, respectively) and caudate (P=.04 and P=.03, respectively) volumes. Inner nuclear layer thickness, also in eyes without a history of optic neuritis, was associated with fluid-attenuated inversion recovery lesion volume (P=.007) and inversely associated with normal-appearing white matter volume (P=.005) in relapsing-remitting MS. As intracranial volume was found to be related with several of the OCT measures in patients with MS and healthy control subjects and is already known to be associated with brain substructure volumes, all OCT-brain substructure relationships were adjusted for intracranial volume. Conclusions: Retinal measures reflect global central nervous system pathology in multiple sclerosis, with thicknesses of discrete retinal layers each appearing to be associated with distinct central nervous system processes. Moreover, OCT measures appear to correlate with intracranial volume in patients with MS and healthy control subjects, an important unexpected factor unaccounted for in prior studies examining the relationships between peripapillary retinal nerve fiber layer thickness and brain substructure volumes.",
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T1 - Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis

AU - Saidha, Shiv

AU - Sotirchos, Elias S.

AU - Oh, Jiwon

AU - Syc, Stephanie B.

AU - Seigo, Michaela A.

AU - Shiee, Navid

AU - Eckstein, Chistopher

AU - Durbin, Mary K.

AU - Oakley, Jonathan D.

AU - Meyer, Scott A.

AU - Frohman, Teresa C.

AU - Newsome, Scott

AU - Ratchford, John N.

AU - Balcer, Laura J.

AU - Pham, Dzung L.

AU - Crainiceanu, Ciprian M.

AU - Frohman, Elliot

AU - Reich, Daniel S.

AU - Calabresi, Peter A.

PY - 2013/1

Y1 - 2013/1

N2 - Objective: To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size) and brain substructure volumes in multiple sclerosis (MS). Design: Cross-sectional study. Setting: Johns Hopkins University, Baltimore, Maryland. Participants: A total of 84 patients with MS and 24 healthy control subjects. Main Outcome Measures: High-definition spectraldomain OCT conventional and automated segmentationderived discrete retinal layer thicknesses and 3-T magnetic resonance imaging brain substructure volumes. Results: Peripapillary retinal nerve fiber layer as well as composite ganglion cell layer + inner plexiform layer thicknesses in the eyes of patients with MS without a history of optic neuritis were associated with cortical gray matter (P=.01 and P=.04, respectively) and caudate (P=.04 and P=.03, respectively) volumes. Inner nuclear layer thickness, also in eyes without a history of optic neuritis, was associated with fluid-attenuated inversion recovery lesion volume (P=.007) and inversely associated with normal-appearing white matter volume (P=.005) in relapsing-remitting MS. As intracranial volume was found to be related with several of the OCT measures in patients with MS and healthy control subjects and is already known to be associated with brain substructure volumes, all OCT-brain substructure relationships were adjusted for intracranial volume. Conclusions: Retinal measures reflect global central nervous system pathology in multiple sclerosis, with thicknesses of discrete retinal layers each appearing to be associated with distinct central nervous system processes. Moreover, OCT measures appear to correlate with intracranial volume in patients with MS and healthy control subjects, an important unexpected factor unaccounted for in prior studies examining the relationships between peripapillary retinal nerve fiber layer thickness and brain substructure volumes.

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