Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice

F. P. Mancini, D. L. Newland, V. Mooser, J. Murata, S. Marcovina, S. G. Young, Robert E Hammer, D. A. Sanan, Helen H Hobbs

Research output: Contribution to journalArticle

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Abstract

Transgenic mice expressing transgenes for both human apolipoprotein B-100 (h-apoB) and apolipoprotein(a) [apo(a)] were fed a high-fat, atherogenic diet for 14 weeks to examine the effect of lipoprotein(a) [Lp(a)] on the development of aortic rally lesions. The extent of lesions in the proximal region of the aorta of Lp(a) mice was measured by use of a computer-assisted image analysis of 20 sections per animal and compared with that of nontransgenic mice as well as mice expressing either the apo(a) or h-apoB transgene. The control (n=23) and apo(a) (n=22) transgenic mice had very small mean lesion areas (607 versus 128 μm2 per section). The h-apoB- expressing mice (n=20) had significantly higher mean lesion areas (3288 μm2 per section) than either the control or apo(a) transgenic animals. Coexpression of apo(a) and h-apoB transgenes resulted in only a modest increase in lesion area (4678 μm2 per section, n=19). Thus, the expression of human apo(a) in C57BL/6/SJL hybrid mice fed an atherogenic diet failed to significantly potentiate the development of aortic fatty lesions in the absence or presence of high levels of h-apoB.

Original languageEnglish (US)
Pages (from-to)1911-1916
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume15
Issue number11
StatePublished - 1995

Fingerprint

Apoprotein(a)
Apolipoprotein B-100
Apolipoproteins B
Aorta
Transgenes
Atherogenic Diet
Lipoprotein(a)
Transgenic Mice
Genetically Modified Animals
Computer-Assisted Image Processing
High Fat Diet

Keywords

  • apo(a)
  • atherosclerosis
  • lipoprotein(a)
  • transgenic mice

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice. / Mancini, F. P.; Newland, D. L.; Mooser, V.; Murata, J.; Marcovina, S.; Young, S. G.; Hammer, Robert E; Sanan, D. A.; Hobbs, Helen H.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 15, No. 11, 1995, p. 1911-1916.

Research output: Contribution to journalArticle

Mancini, F. P. ; Newland, D. L. ; Mooser, V. ; Murata, J. ; Marcovina, S. ; Young, S. G. ; Hammer, Robert E ; Sanan, D. A. ; Hobbs, Helen H. / Relative contributions of apolipoprotein(a) and apolipoprotein-B to the development of fatty lesions in the proximal aorta of mice. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1995 ; Vol. 15, No. 11. pp. 1911-1916.
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AU - Mancini, F. P.

AU - Newland, D. L.

AU - Mooser, V.

AU - Murata, J.

AU - Marcovina, S.

AU - Young, S. G.

AU - Hammer, Robert E

AU - Sanan, D. A.

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