Renal injury mediated calcium oxalate nephrolithiasis

Role of lipid peroxidation

Alagarraju Muthukumar, Ramasamy Selvam

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The role of lipid peroxidation (LPO) in renal tubular damage mediated calcium oxalate retention was investigated in a rat model. Hyperoxaluria, without deposition of oxalate in kidney, was induced by administration of ethylene glycol (EG), a precursor of oxalate. Oxidative stress condition was produced by administration of buthionine sulfoximine (BSO), an inhibitor of glutathione biosynthesis. BSO-treated rats showed a significant (p < 0.001) increase in LPO over EG-treated rats and it was almost doubled in BSO + EG treated rats. LPO was accompanied by significant urinary excretion of renal damage marker enzymes such as γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP) and cathepsin D, mucoproteins, and glycosaminoglycans (GAGs) in the BSO and BSO + EG groups but not in the EG group. Urinary excretion of γ-GT (r = +0.90) (p < 0.001) and deposition of oxalate (r = +0.78) (p < 0.001) in kidney positively correlated with LPO. These results suggest that LPO initiates renal damage, thereby leading to calcium oxalate retention and stone formation.

Original languageEnglish (US)
Pages (from-to)401-408
Number of pages8
JournalRenal Failure
Volume19
Issue number3
StatePublished - 1997

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Buthionine Sulfoximine
Ethylene Glycol
Lipid Peroxidation
Oxalates
Kidney
Wounds and Injuries
Calcium Oxalate
Mucoproteins
Hyperoxaluria
Cathepsin D
gamma-Glutamyltransferase
Glycosaminoglycans
Glutathione
Alkaline Phosphatase
Oxidative Stress
Calcium Oxalate Nephrolithiasis
Enzymes

ASJC Scopus subject areas

  • Nephrology

Cite this

Renal injury mediated calcium oxalate nephrolithiasis : Role of lipid peroxidation. / Muthukumar, Alagarraju; Selvam, Ramasamy.

In: Renal Failure, Vol. 19, No. 3, 1997, p. 401-408.

Research output: Contribution to journalArticle

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