Renal senescence in 2008: Progress and challenges

Xin J. Zhou, Ramesh Saxena, Zhihong Liu, N. D. Vaziri, Fred G. Silva

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.

Original languageEnglish (US)
Pages (from-to)823-839
Number of pages17
JournalInternational Urology and Nephrology
Volume40
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Kidney
Telomere
Renin-Angiotensin System
Drug-Related Side Effects and Adverse Reactions
Glomerular Filtration Rate
Health Care Costs
Electrolytes
Potassium
Oxidative Stress
Morbidity
Gene Expression
Mortality
Population

Keywords

  • Aging
  • Geriatric nephrology
  • Klotho
  • Oxidative stress
  • Renal pathology
  • Senescence
  • Telomeres

ASJC Scopus subject areas

  • Nephrology
  • Urology
  • Geriatrics and Gerontology

Cite this

Renal senescence in 2008 : Progress and challenges. / Zhou, Xin J.; Saxena, Ramesh; Liu, Zhihong; Vaziri, N. D.; Silva, Fred G.

In: International Urology and Nephrology, Vol. 40, No. 3, 09.2008, p. 823-839.

Research output: Contribution to journalArticle

Zhou, Xin J. ; Saxena, Ramesh ; Liu, Zhihong ; Vaziri, N. D. ; Silva, Fred G. / Renal senescence in 2008 : Progress and challenges. In: International Urology and Nephrology. 2008 ; Vol. 40, No. 3. pp. 823-839.
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