Respiratory plasticity following intermittent hypoxia: Roles of protein phosphatases and reactive oxygen species

J. E R Wilkerson, P. M. MacFarlane, M. S. Hoffman, G. S. Mitchell

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Plasticity is an important property of the respiratory control system. One of the best-studied models of respiratory plasticity is pLTF (phrenic long-term facilitation). pLTF is a progressive increase in phrenic motor output lasting several hours following acute exposure to intermittent hypoxia. Similar to many other forms of neuroplasticity, pLTF is pattern-sensitive; it is induced by intermittent, but not sustained hypoxia of similar cumulative duration. Our understanding of the cellular/synaptic mechanisms underlying pLTF has increased considerably in recent years. Here, we review accumulating evidence suggesting that the pattern-sensitivity of pLTF arises substantially from differential reactive oxygen species formation and subsequent protein phosphatase inhibition during intermittent compared with sustained hypoxia in or near phrenic motor neurons. A detailed understanding of the cellular/synaptic mechanisms of pLTF may provide the rationale for new pharmacological approaches in the treatment of severe ventilatory control disorders, such as obstructive sleep apnoea and respiratory insufficiency either following spinal cord injury or during neurodegenerative diseases such as amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)1269-1272
Number of pages4
JournalBiochemical Society Transactions
Volume35
Issue number5
DOIs
StatePublished - Nov 2007

Fingerprint

Phosphoprotein Phosphatases
Diaphragm
Plasticity
Reactive Oxygen Species
Neurodegenerative diseases
Neurons
Control systems
Neuronal Plasticity
Hypoxia
Amyotrophic Lateral Sclerosis
Motor Neurons
Obstructive Sleep Apnea
Spinal Cord Injuries
Respiratory Insufficiency
Neurodegenerative Diseases
Respiratory System
Pharmacology
Sleep

Keywords

  • 5-hydroxytryptamine (5-HT)
  • Brain-derived neurotrophic factor (BDNF)
  • Long-term facilitation
  • Pattern-sensitivity
  • Phosphorylation
  • Plasticity

ASJC Scopus subject areas

  • Biochemistry

Cite this

Respiratory plasticity following intermittent hypoxia : Roles of protein phosphatases and reactive oxygen species. / Wilkerson, J. E R; MacFarlane, P. M.; Hoffman, M. S.; Mitchell, G. S.

In: Biochemical Society Transactions, Vol. 35, No. 5, 11.2007, p. 1269-1272.

Research output: Contribution to journalArticle

Wilkerson, J. E R ; MacFarlane, P. M. ; Hoffman, M. S. ; Mitchell, G. S. / Respiratory plasticity following intermittent hypoxia : Roles of protein phosphatases and reactive oxygen species. In: Biochemical Society Transactions. 2007 ; Vol. 35, No. 5. pp. 1269-1272.
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