Respiratory variation and cardiopulmonary interactions

Russell S. Roberson

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


It is often unclear whether or not a patient's stroke volume will increase following a fluid bolus. Volume responsiveness is defined by an increase in stroke volume following a fluid bolus. For patients being mechanically ventilated, the cardiopulmonary interactions associated with positive pressure ventilation create pulse pressure and stroke volume variation in the arterial pressure waveform that can be used to assess fluid responsiveness, socalled dynamic preload assessment. However, lung-protective ventilation is increasingly being used to avoid the adverse outcomesof higher tidal volume ventilation, and pulse pressure and stroke volume variation do not effectively predict volume responsiveness in the setting of lung-protective ventilation without using special techniques. Dynamic preload assessment is more effective at determining whether a patient will be fluid responsive than static measures of preload, but further studies are needed to more conclusively show that outcomes are improved with this approach to fluid management.

Original languageEnglish (US)
Pages (from-to)407-418
Number of pages12
JournalBest Practice and Research: Clinical Anaesthesiology
Issue number4
StatePublished - Jan 1 2014


  • Acute respiratory distress syndrome
  • Dynamic preload assessment
  • Fluid responsiveness
  • Fluid therapy
  • Hypovolaemia
  • Pulse contour analysis
  • Pulse pressure variation
  • Stroke volume variation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Respiratory variation and cardiopulmonary interactions'. Together they form a unique fingerprint.

Cite this