TY - GEN
T1 - Response of Chemically-Crosslinked Microbubble Clusters to Low-Intensity Pulsed Ultrasound
AU - Hall, Ronald L.
AU - Juan-Sing Dennis, Zachary
AU - Hoyt, Kenneth
AU - Sirsi, Shashank R.
N1 - Funding Information:
This work was supported in part by the NCI grant number
Publisher Copyright:
© 2019 IEEE.
PY - 2019/10
Y1 - 2019/10
N2 - Ultrasound contrast agents (UCAs- also known as "microbubbles") are small gas particles that volumetrically expand and contract in an ultrasound field, creating a backscattered signal. Their application in imaging and therapy is rapidly growing, requiring continuous optimization to meet the demands of emerging applications. We have recently developed and published a new class of lipid-based UCAs that called chemically cross-linked microbubbles clusters (CCMCs). Unlike individual UCAs, CCMCs are uniquely able to undergo ultrasound-induced bubble fusion using low-intensity pulsed ultrasound. In this study, we continue to optimize or formulation process to develop a rapid and facile means of generating usable and stable clusters for in vivo delivery. Our overall hypothesis is that the unique fusion response of CCMCs in an ultrasound field can generate novel acoustic responses and will eventually enable new methods of contrast agent imaging which cannot be accomplished with traditional UCAs.
AB - Ultrasound contrast agents (UCAs- also known as "microbubbles") are small gas particles that volumetrically expand and contract in an ultrasound field, creating a backscattered signal. Their application in imaging and therapy is rapidly growing, requiring continuous optimization to meet the demands of emerging applications. We have recently developed and published a new class of lipid-based UCAs that called chemically cross-linked microbubbles clusters (CCMCs). Unlike individual UCAs, CCMCs are uniquely able to undergo ultrasound-induced bubble fusion using low-intensity pulsed ultrasound. In this study, we continue to optimize or formulation process to develop a rapid and facile means of generating usable and stable clusters for in vivo delivery. Our overall hypothesis is that the unique fusion response of CCMCs in an ultrasound field can generate novel acoustic responses and will eventually enable new methods of contrast agent imaging which cannot be accomplished with traditional UCAs.
KW - Bubble Coalescence
KW - Microbubbles
KW - Ostwald Ripening
KW - Ultrasound contrast agents
UR - http://www.scopus.com/inward/record.url?scp=85077564075&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2019.8926042
DO - 10.1109/ULTSYM.2019.8926042
M3 - Conference contribution
AN - SCOPUS:85077564075
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 1361
EP - 1363
BT - 2019 IEEE International Ultrasonics Symposium, IUS 2019
PB - IEEE Computer Society
T2 - 2019 IEEE International Ultrasonics Symposium, IUS 2019
Y2 - 6 October 2019 through 9 October 2019
ER -