Response of Chemically-Crosslinked Microbubble Clusters to Low-Intensity Pulsed Ultrasound

Ronald L. Hall, Zachary Juan-Sing Dennis, Kenneth Hoyt, Shashank R. Sirsi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrasound contrast agents (UCAs- also known as "microbubbles") are small gas particles that volumetrically expand and contract in an ultrasound field, creating a backscattered signal. Their application in imaging and therapy is rapidly growing, requiring continuous optimization to meet the demands of emerging applications. We have recently developed and published a new class of lipid-based UCAs that called chemically cross-linked microbubbles clusters (CCMCs). Unlike individual UCAs, CCMCs are uniquely able to undergo ultrasound-induced bubble fusion using low-intensity pulsed ultrasound. In this study, we continue to optimize or formulation process to develop a rapid and facile means of generating usable and stable clusters for in vivo delivery. Our overall hypothesis is that the unique fusion response of CCMCs in an ultrasound field can generate novel acoustic responses and will eventually enable new methods of contrast agent imaging which cannot be accomplished with traditional UCAs.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages1361-1363
Number of pages3
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Externally publishedYes
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

Keywords

  • Bubble Coalescence
  • Microbubbles
  • Ostwald Ripening
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Hall, R. L., Juan-Sing Dennis, Z., Hoyt, K., & Sirsi, S. R. (2019). Response of Chemically-Crosslinked Microbubble Clusters to Low-Intensity Pulsed Ultrasound. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 1361-1363). [8926042] (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8926042