Responses of muscle sympathetic nerve activity to lower body positive pressure

Qi Fu, Yoshiki Sugiyama, A. Atsunori Kamiya, S. M. Shamsuzzaman, Tadaaki Mano

Research output: Contribution to journalArticle

Abstract

To evaluate the response of vasomotor sympathetic nerve activity to lower body positive pressure (LBPP), muscle sympathetic nerve activity (MSNA) was microneurographically recorded from the tibial nerve in 10 healthy young men, along with hemodynamic variables and echocardiogram, during exposure to incremental LBPP at 10, 20, and 30 mmHg in the supine position. MSNA was suppressed to a similar extent (27%) at 10- and 20-mmHg LBPP. However, at 30- mmHg LBPP, MSNA tended to increase but was still nearly at the control value. Mean arterial pressure was elevated (11%), total peripheral resistance markedly increased (36%), and stroke volume and cardiac output tended to decrease at 30-mmHg LBPP. Heart rate remained unchanged throughout the procedures. Left atrial dimension significantly increased during 10- and 30- mmHg LBPP, indicating an increased cardiac filling. These results suggest that the inhibitory effect of the cardiopulmonary baroreflex on MSNA at 10- and 20-mmHg LBPP could be counteracted by the sympathoexcitatory effect of the intramuscular pressure-sensitive mechanoreflex at 30-mmHg LBPP. However, the increment of total peripheral resistance at 30-mmHg LBPP may not depend exclusively on this small enhancement of MSNA.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume275
Issue number4 44-4
StatePublished - 1998

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Pressure
Muscles
Vascular Resistance
Tibial Nerve
Baroreflex
Supine Position
Cardiac Output
Stroke Volume
Arterial Pressure
Heart Rate
Hemodynamics

Keywords

  • Cardiopulmonary baroreceptor
  • Intramuscular pressure-sensitive receptor

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Responses of muscle sympathetic nerve activity to lower body positive pressure. / Fu, Qi; Sugiyama, Yoshiki; Atsunori Kamiya, A.; Shamsuzzaman, S. M.; Mano, Tadaaki.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 275, No. 4 44-4, 1998.

Research output: Contribution to journalArticle

Fu, Qi ; Sugiyama, Yoshiki ; Atsunori Kamiya, A. ; Shamsuzzaman, S. M. ; Mano, Tadaaki. / Responses of muscle sympathetic nerve activity to lower body positive pressure. In: American Journal of Physiology - Heart and Circulatory Physiology. 1998 ; Vol. 275, No. 4 44-4.
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