Restoration of the cellular senescence program and repression of telomerase by human chromosome 3

Hiroshi Ohmura, Hidetoshi Tahara, Mikio Suzuki, Toshinori Ide, Motoyuki Shimizu, Mitsuaki A. Yoshida, Eiichi Tahara, Jerry W. Shay, J. Carl Barrett, Mitsuo Oshimura

Research output: Contribution to journalArticle

Abstract

Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.

Original languageEnglish (US)
Pages (from-to)899-904
Number of pages6
JournalJapanese Journal of Cancer Research
Volume86
Issue number10
DOIs
StatePublished - Oct 1995

Keywords

  • Cellular senescence
  • Chromosome 3
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Restoration of the cellular senescence program and repression of telomerase by human chromosome 3'. Together they form a unique fingerprint.

  • Cite this

    Ohmura, H., Tahara, H., Suzuki, M., Ide, T., Shimizu, M., Yoshida, M. A., Tahara, E., Shay, J. W., Barrett, J. C., & Oshimura, M. (1995). Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Japanese Journal of Cancer Research, 86(10), 899-904. https://doi.org/10.1016/0910-5050(95)96782-Z