Resveratrol oligomers from Vitis amurensis attenuate β-amyloid-induced oxidative stress in PC12 cells

Moon Hee Jang, Xiang Lan Piao, Hyun Young Kim, Eun Jung Cho, Seung Hoon Baek, Sung Won Kwon, Jeong Hill Park

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Oxidative damage induced by β-amyloid (Aβ) is closely associated with the hallmark pathologies of Alzheimer's disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from Vitis amurensis RUPR. (Vitaceae), against Aβ-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the Aβ (20 μM) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5-50 μM reduced Aβ-induced cell death. In addition, Aβ-induced elevation of reactive oxygen species generation, the primary cause of Aβ-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 μM). Aβ-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 μM) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent Aβ-induced neurotoxicity through attenuating oxidative stress induced by Aβ, and may be useful as potential preventive or therapeutic agents for AD.

Original languageEnglish (US)
Pages (from-to)1130-1134
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Alzheimer's disease
  • Heyneanol A
  • Reactive oxygen species
  • Resveratrol oligomer
  • Vitis amurensis
  • Vitisin A
  • β-amyloid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Jang, M. H., Piao, X. L., Kim, H. Y., Cho, E. J., Baek, S. H., Kwon, S. W., & Park, J. H. (2007). Resveratrol oligomers from Vitis amurensis attenuate β-amyloid-induced oxidative stress in PC12 cells. Biological and Pharmaceutical Bulletin, 30(6), 1130-1134. https://doi.org/10.1248/bpb.30.1130