Retrospective evaluation of the efficacy and safety of belatacept with thymoglobulin induction and maintenance everolimus: A single-center clinical experience

David Wojciechowski, Sindhu Chandran, Joshua Y.C. Yang, Minnie M. Sarwal, Flavio Vincenti

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Belatacept use has been constrained by higher rates of acute rejection. We hypothesized that belatacept with low-dose rATG and initial mycophenolate maintenance with conversion to everolimus at 1 month post-transplant ± corticosteroids would improve efficacy and maintain safety. Retrospective single-center analysis of the first 44 low immunologic risk kidney transplant recipients treated with this regimen. The cohort was 59% male, mean age at transplant of 57 years. Diabetes was the most common cause of ESRD (39%). The mean 1-year eGFR was 61.4 (SD 18.4) mL/min/1.73 m2. There were five acute cellular rejections (11.4%) that occurred in patients who had changed from everolimus to mycophenolate mofetil due to side effects. Thirty-two percent developed BK viremia and 12% developed CMV viremia. There were no cases of PTLD. A novel belatacept regimen with rATG induction and maintenance everolimus demonstrated a low acute rejection rate and maintained an excellent 1-year eGFR.

Original languageEnglish (US)
Article numbere13042
JournalClinical Transplantation
Volume31
Issue number9
DOIs
StatePublished - Sep 2017
Externally publishedYes

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Keywords

  • Fusion proteins: belatacept, immunosuppressant
  • Immunosuppressant
  • mechanistic target of rapamycin: everolimus, immunosuppressive regimens

ASJC Scopus subject areas

  • Transplantation

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