Reversible protection of lysine to facilitate the purification of protected peptide segments

Josep Rizo; Fernando Albericio; Ernest Giralt; Enrique Pedroso

doi:10.1016/S0040-4039(00)74141-4

Reversible protection of lysine to facilitate the purification of protected peptide segments

Josep Rizo, Fernando Albericio, Ernest Giralt, Enrique Pedroso

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE¹ can cause trifluoroacetylation of free primary amines.

Original language	English (US)
Pages (from-to)	397-400
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/S0040-4039(00)74141-4
State	Published - Jan 14 1992

Keywords

Nbb-resin
amine trifluoroacetylation
lysine protection
peptide synthesis
protected peptide segments

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)74141-4

Cite this

@article{f88be82d3aee45dd9386486a3b2af46a,

title = "Reversible protection of lysine to facilitate the purification of protected peptide segments",

abstract = "The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.",

keywords = "Nbb-resin, amine trifluoroacetylation, lysine protection, peptide synthesis, protected peptide segments",

author = "Josep Rizo and Fernando Albericio and Ernest Giralt and Enrique Pedroso",

year = "1992",

month = jan,

day = "14",

doi = "10.1016/S0040-4039(00)74141-4",

language = "English (US)",

volume = "33",

pages = "397--400",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Reversible protection of lysine to facilitate the purification of protected peptide segments

AU - Rizo, Josep

AU - Albericio, Fernando

AU - Giralt, Ernest

AU - Pedroso, Enrique

PY - 1992/1/14

Y1 - 1992/1/14

N2 - The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.

AB - The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.

KW - Nbb-resin

KW - amine trifluoroacetylation

KW - lysine protection

KW - peptide synthesis

KW - protected peptide segments

UR - http://www.scopus.com/inward/record.url?scp=0026601341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026601341&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)74141-4

DO - 10.1016/S0040-4039(00)74141-4

M3 - Article

AN - SCOPUS:0026601341

SN - 0040-4039

VL - 33

SP - 397

EP - 400

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 3

ER -

Reversible protection of lysine to facilitate the purification of protected peptide segments

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this