Reversible protection of lysine to facilitate the purification of protected peptide segments

Josep Rizo, Fernando Albericio, Ernest Giralt, Enrique Pedroso

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.

Original languageEnglish (US)
Pages (from-to)397-400
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number3
DOIs
StatePublished - Jan 14 1992

Fingerprint

Lysine
Amines
Purification
Peptides
Impurities

Keywords

  • amine trifluoroacetylation
  • lysine protection
  • Nbb-resin
  • peptide synthesis
  • protected peptide segments

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Reversible protection of lysine to facilitate the purification of protected peptide segments. / Rizo, Josep; Albericio, Fernando; Giralt, Ernest; Pedroso, Enrique.

In: Tetrahedron Letters, Vol. 33, No. 3, 14.01.1992, p. 397-400.

Research output: Contribution to journalArticle

Rizo, Josep ; Albericio, Fernando ; Giralt, Ernest ; Pedroso, Enrique. / Reversible protection of lysine to facilitate the purification of protected peptide segments. In: Tetrahedron Letters. 1992 ; Vol. 33, No. 3. pp. 397-400.
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