@article{cff755a0e9ed4d3da26ef1d002cc45a9,
title = "Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors",
abstract = "Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.",
keywords = "APT-weighted imaging, APTw standardization, brain tumor, CEST imaging",
author = "Jinyuan Zhou and Moritz Zaiss and Linda Knutsson and Sun, {Phillip Zhe} and Ahn, {Sung Soo} and Silvio Aime and Peter Bachert and Blakeley, {Jaishri O.} and Kejia Cai and Chappell, {Michael A.} and Min Chen and Gochberg, {Daniel F.} and Steffen Goerke and Heo, {Hye Young} and Shanshan Jiang and Tao Jin and Kim, {Seong Gi} and John Laterra and Daniel Paech and Pagel, {Mark D.} and Park, {Ji Eun} and Ravinder Reddy and Akihiko Sakata and Sabine Sartoretti-Schefer and Sherry, {A. Dean} and Smith, {Seth A.} and Stanisz, {Greg J.} and Sundgren, {Pia C.} and Osamu Togao and Moriel Vandsburger and Zhibo Wen and Yin Wu and Yi Zhang and Wenzhen Zhu and Zhongliang Zu and {van Zijl}, {Peter C.M.}",
note = "Funding Information: information German Research Foundation (DFG), 445704496; National Research Foundation of Korea (NRF), 2014R1A1A1002716; National Institutes of Health, P41EB015909; P41EB029460; R01AG069179; R01CA228188; R01EB015032; R37CA248077; Swedish Cancer Society, CAN 2015/251; CAN 2018/468; CAN 2018/550; Swedish Research Council, 2015-04170; 2019-01162We thank Drs. Weiqiang Dou, Mitsuharu Miyoshi, and Bin Wu (GE Healthcare), Drs. Queenie Chan, Weibo Chen, Shuguang Hu, Jochen Keupp, Eunju Kim, Kim van de Ven, Michael Wyss, Masami Yoneyama, Xuna Zhao, and Yansong Zhao (Philips Healthcare), Drs. Yi-Cheng Hsu, Patrick Liebig, Li Pan, Benjamin Schmitt and Yi Sun (Siemens Healthineers), and Dr. Stefano Casagranda (Olea Medical) for help and suggestions over the years. We thank Drs. Sotirios Bisdas and Laura Mancini (University College London Hospitals NHS Foundation Trust and UCL Queen Square Institute of Neurology, London, United Kingdom) for kindly providing their unpublished Figure 10D and related explanation. We also thank Dr. Wilfred W. Lam (Sunnybrook Research Institute) for many helpful discussions. Funding information: National Institutes of Health, Grant/Award Numbers: R01CA228188 and R01AG069179 (to J.Z.); R37CA248077 (to S.J.); P41EB029460 (to R.R.); P41EB015909 and R01EB015032 (to P.C.M.v.Z.); Swedish Research Council, Grant Numbers: 2015-04170 (to L.K.); 2019-01162 (to P.C.S.); Swedish Cancer Society, Grant Numbers: CAN 2015/251 and CAN 2018/550 (to L.K.); CAN 2018/468 (to P.C.S.); National Research Foundation of Korea (NRF), Grant number: 2014R1A1A1002716 (to S.S.A.); German Research Foundation (DFG), Grant number: 445704496 (to D.P.). Funding Information: German Research Foundation (DFG), 445704496; National Research Foundation of Korea (NRF), 2014R1A1A1002716; National Institutes of Health, P41EB015909; P41EB029460; R01AG069179; R01CA228188; R01EB015032; R37CA248077; Swedish Cancer Society, CAN 2015/251; CAN 2018/468; CAN 2018/550; Swedish Research Council, 2015‐04170; 2019‐01162 Funding information Funding Information: We thank Drs. Weiqiang Dou, Mitsuharu Miyoshi, and Bin Wu (GE Healthcare), Drs. Queenie Chan, Weibo Chen, Shuguang Hu, Jochen Keupp , Eunju Kim, Kim van de Ven, Michael Wyss, Masami Yoneyama, Xuna Zhao, and Yansong Zhao (Philips Healthcare), Drs. Yi‐Cheng Hsu, Patrick Liebig, Li Pan, Benjamin Schmitt and Yi Sun (Siemens Healthineers), and Dr. Stefano Casagranda (Olea Medical) for help and suggestions over the years. We thank Drs. Sotirios Bisdas and Laura Mancini (University College London Hospitals NHS Foundation Trust and UCL Queen Square Institute of Neurology, London, United Kingdom) for kindly providing their unpublished Figure 10D and related explanation. We also thank Dr. Wilfred W. Lam (Sunnybrook Research Institute) for many helpful discussions. Funding information: National Institutes of Health, Grant/Award Numbers: R01CA228188 and R01AG069179 (to J.Z.); R37CA248077 (to S.J.); P41EB029460 (to R.R.); P41EB015909 and R01EB015032 (to P.C.M.v.Z.); Swedish Research Council, Grant Numbers: 2015‐04170 (to L.K.); 2019‐01162 (to P.C.S.); Swedish Cancer Society, Grant Numbers: CAN 2015/251 and CAN 2018/550 (to L.K.); CAN 2018/468 (to P.C.S.); National Research Foundation of Korea (NRF), Grant number: 2014R1A1A1002716 (to S.S.A.); German Research Foundation (DFG), Grant number: 445704496 (to D.P.). Publisher Copyright: {\textcopyright} 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.",
year = "2022",
month = aug,
doi = "10.1002/mrm.29241",
language = "English (US)",
volume = "88",
pages = "546--574",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",
}