Review of low-grade gliomas in children—evolving molecular era and therapeutic insights

Soumen Khatua; Jason Wang; Veena Rajaram

doi:10.1007/s00381-015-2653-2

Review of low-grade gliomas in children—evolving molecular era and therapeutic insights

Soumen Khatua, Jason Wang, Veena Rajaram

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Low-grade gliomas are the commonest brain tumor in children comprising heterogeneous pathological entities. Though the overall prognosis is good, unresectable, and recurrent or progressive tumors in eloquent areas of the brain remain major therapeutic challenge even with advances in chemotherapeutic strategies. With the evolving surge of molecular data, improved understanding of the biology of these tumors is now perceivable that could provide insights into novel therapies. We hope the new era will enable us to profile comprehensive histopathological/molecular classification and prognostic molecular markers in these tumors and guide us to tailor optimal targeted therapy.

Original language	English (US)
Pages (from-to)	643-652
Number of pages	10
Journal	Child's Nervous System
Volume	31
Issue number	5
DOIs	https://doi.org/10.1007/s00381-015-2653-2
State	Published - May 1 2015

Keywords

Histopathology
Low-grade gliomas
Molecular biology
Therapeutic insights

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1007/s00381-015-2653-2

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abstract = "Low-grade gliomas are the commonest brain tumor in children comprising heterogeneous pathological entities. Though the overall prognosis is good, unresectable, and recurrent or progressive tumors in eloquent areas of the brain remain major therapeutic challenge even with advances in chemotherapeutic strategies. With the evolving surge of molecular data, improved understanding of the biology of these tumors is now perceivable that could provide insights into novel therapies. We hope the new era will enable us to profile comprehensive histopathological/molecular classification and prognostic molecular markers in these tumors and guide us to tailor optimal targeted therapy.",

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AU - Rajaram, Veena

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N2 - Low-grade gliomas are the commonest brain tumor in children comprising heterogeneous pathological entities. Though the overall prognosis is good, unresectable, and recurrent or progressive tumors in eloquent areas of the brain remain major therapeutic challenge even with advances in chemotherapeutic strategies. With the evolving surge of molecular data, improved understanding of the biology of these tumors is now perceivable that could provide insights into novel therapies. We hope the new era will enable us to profile comprehensive histopathological/molecular classification and prognostic molecular markers in these tumors and guide us to tailor optimal targeted therapy.

AB - Low-grade gliomas are the commonest brain tumor in children comprising heterogeneous pathological entities. Though the overall prognosis is good, unresectable, and recurrent or progressive tumors in eloquent areas of the brain remain major therapeutic challenge even with advances in chemotherapeutic strategies. With the evolving surge of molecular data, improved understanding of the biology of these tumors is now perceivable that could provide insights into novel therapies. We hope the new era will enable us to profile comprehensive histopathological/molecular classification and prognostic molecular markers in these tumors and guide us to tailor optimal targeted therapy.

KW - Histopathology

KW - Low-grade gliomas

KW - Molecular biology

KW - Therapeutic insights

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Review of low-grade gliomas in children—evolving molecular era and therapeutic insights

Abstract

Keywords

ASJC Scopus subject areas

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