Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells

Laurie S. Davis, John J. Cush, Hendrik Schulze-Koops, Peter E. Lipsky

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-γ alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effectors. Normal and RAPB Tm differentiated into both IFN-γ and IL-4-producing effectors. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-γ and IL-4 producers.

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalArthritis research
Volume3
Issue number1
DOIs
StatePublished - Mar 29 2001

Keywords

  • CD4 T-helper cells
  • Cytokines
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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