Abstract
CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-γ alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effectors. Normal and RAPB Tm differentiated into both IFN-γ and IL-4-producing effectors. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-γ and IL-4 producers.
Original language | English (US) |
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Pages (from-to) | 54-64 |
Number of pages | 11 |
Journal | Arthritis research |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Keywords
- CD4 T-helper cells
- Cytokines
- Rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology