Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells

Laurie S. Davis, John J. Cush, Hendrik Schulze-Koops, Peter E. Lipsky

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-γ alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effectors. Normal and RAPB Tm differentiated into both IFN-γ and IL-4-producing effectors. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-γ and IL-4 producers.

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalArthritis Research
Volume3
Issue number1
DOIs
StatePublished - 2001

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Th2 Cells
Interleukin-4
Rheumatoid Arthritis
T-Lymphocytes
Interleukin-2
Synovial Fluid
Blood Donors

Keywords

  • CD4 T-helper cells
  • Cytokines
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells. / Davis, Laurie S.; Cush, John J.; Schulze-Koops, Hendrik; Lipsky, Peter E.

In: Arthritis Research, Vol. 3, No. 1, 2001, p. 54-64.

Research output: Contribution to journalArticle

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