Rhythmic properties of the hamster suprachiasmatic nucleus in vivo

Shin Yamazaki, Marie C. Kerbeshian, Craig G. Hocker, Gene D. Block, Michael Menaker

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

We recorded multiple unit neural activity [multiunit activity (MUA)] from inside and outside of the suprachiasmatic nucleus (SCN) in freely moving male golden hamsters housed in running-wheel cages under both light/dark cycles and constant darkness. The circadian period of MUA in the SCN matched the period of locomotor activity; it was ~24 hr in wild-type and 20 hr in homozygous tau mutant hamsters. The peak of MUA in the SCN always occurred in the middle of the day or, in constant darkness, the subjective day. There were circadian rhythms of MUA outside of the SCN in the ventrolateral thalamic nucleus, the caudate putamen, the accumbens nucleus, the medial septum, the lateral septum, the ventromedial hypothalamic nucleus, the medial preoptic region, and the stria medullaris. These rhythms were out-of-phase with the electrical rhythm in the SCN but in-phase with the rhythm of locomotor activity, peaking during the night or subjective night. In addition to circadian rhythms, there were significant ultradian rhythms present; one, with a period of ~80 min, was in antiphase between the SCN and other brain areas, and another, with a period of ~14 min, was in-phase between the SCN and other brain areas. The periods of these ultradian rhythms were not significantly different in wild-type and tau mutant hamsters. Of particular interest was the unique phase relationship between the MUA of the bed nucleus of the stria terminalis (BNST) and the SCN; in these two areas both circadian and ultradian components were always in-phase. This suggests that the BNST is strongly coupled to the SCN and may be one of its major output pathways. In addition to circadian and ultradian rhythms of MUA, neural activity both within and outside the SCN was acutely affected by locomotor activity. Whenever a hamster ran on its wheel, MUA in the SCN and the BNST was suppressed, and MUA in other areas was enhanced.

Original languageEnglish (US)
Pages (from-to)10709-10723
Number of pages15
JournalJournal of Neuroscience
Volume18
Issue number24
StatePublished - Dec 15 1998

Fingerprint

Suprachiasmatic Nucleus
Cricetinae
Septal Nuclei
Locomotion
Circadian Rhythm
Darkness
Ventromedial Hypothalamic Nucleus
Ventral Thalamic Nuclei
Putamen
Mesocricetus
Photoperiod
Brain
Running

Keywords

  • Bed nucleus of the stria terminalis
  • Circadian
  • Hamster
  • In vivo recording
  • Locomotor activity
  • MUA
  • Suprachiasmatic nucleus
  • Tau mutant
  • Ultradian

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yamazaki, S., Kerbeshian, M. C., Hocker, C. G., Block, G. D., & Menaker, M. (1998). Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. Journal of Neuroscience, 18(24), 10709-10723.

Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. / Yamazaki, Shin; Kerbeshian, Marie C.; Hocker, Craig G.; Block, Gene D.; Menaker, Michael.

In: Journal of Neuroscience, Vol. 18, No. 24, 15.12.1998, p. 10709-10723.

Research output: Contribution to journalArticle

Yamazaki, S, Kerbeshian, MC, Hocker, CG, Block, GD & Menaker, M 1998, 'Rhythmic properties of the hamster suprachiasmatic nucleus in vivo', Journal of Neuroscience, vol. 18, no. 24, pp. 10709-10723.
Yamazaki S, Kerbeshian MC, Hocker CG, Block GD, Menaker M. Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. Journal of Neuroscience. 1998 Dec 15;18(24):10709-10723.
Yamazaki, Shin ; Kerbeshian, Marie C. ; Hocker, Craig G. ; Block, Gene D. ; Menaker, Michael. / Rhythmic properties of the hamster suprachiasmatic nucleus in vivo. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 24. pp. 10709-10723.
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