Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo

Chulhong Kim, Kwang Hyun Song, Konstantin Maslov, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in both transmission and reflection modes. These systems used intense acoustic bursts and a charge-coupled device camera-based speckle contrast detection method. By mounting an ultrasound transducer into an optical condenser, we can combine the illuminating light component with the ultrasound transducer. Thus, the UOT system is more clinically applicable than previous orthogonal mode systems. Furthermore, we have successfully imaged an ex vivo methylene-blue-dyed sentinel lymph node (SLN) embedded deeper than 12 mm, the mean depth of human sentinel lymph nodes, in chicken breast tissue. These UOT systems offer several advantages: noninvasiveness, nonionizing radiation, portability, cost-effectiveness, and possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT systems is mapping SLNs in axillary staging for breast cancer patients.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7177
DOIs
StatePublished - 2009
EventPhotons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States
Duration: Jan 25 2009Jan 28 2009

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2009
CountryUnited States
CitySan Jose, CA
Period1/25/091/28/09

Fingerprint

Optical Tomography
lymphatic system
Optical tomography
Ultrasound
Illumination
tomography
Lighting
Ultrasonics
illumination
Ring
rings
Vertex of a graph
breast
transducers
chickens
cost effectiveness
Transducer
condensers
methylene blue
mounting

Keywords

  • Axillary lymph node dissection
  • Breast cancer
  • Ring-shaped light illumination
  • Sentinel lymph node biopsy
  • Ultrasound-modulated optical tomography

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Kim, C., Song, K. H., Maslov, K., & Wang, L. V. (2009). Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7177). [71771F] https://doi.org/10.1117/12.808309

Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo. / Kim, Chulhong; Song, Kwang Hyun; Maslov, Konstantin; Wang, Lihong V.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177 2009. 71771F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, C, Song, KH, Maslov, K & Wang, LV 2009, Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7177, 71771F, Photons Plus Ultrasound: Imaging and Sensing 2009, San Jose, CA, United States, 1/25/09. https://doi.org/10.1117/12.808309
Kim C, Song KH, Maslov K, Wang LV. Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177. 2009. 71771F https://doi.org/10.1117/12.808309
Kim, Chulhong ; Song, Kwang Hyun ; Maslov, Konstantin ; Wang, Lihong V. / Ring-shaped light illumination ultrasound-modulated optical tomography and its application for sentinel lymph node mapping ex vivo. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177 2009.
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