Risk factors for major bleeding and for minor bleeding after percutaneous coronary intervention in 634 consecutive patients with acute coronary syndromes

Bredy Pierre-Louis, Wilbert S. Aronow, Joo H. Yoon, Chul Ahn, Kumar Kalapatapu, Anthony L. Pucillo, Craig E. Monsen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Of 634 consecutive patients who had percutaneous coronary intervention (PCI) for acute coronary syndromes, 34 (5%) had major bleeding after PCI, 253 (40%) had minor bleeding after PCI, and 347 (55%) had no bleeding after PCI. Significant independent risk factors for major bleeding after PCI were increased troponin I level (P = 0.004; odds ratio [OR] = 4.7), prior coronary artery disease (P = 0.029; OR = 3.7), platelet glycoprotein IIb/IIIa inhibitors (P = 0.002; OR = 9.8), glomerular filtration rate (GFR) <30 versus ≥60 mL/min/1.73 m (P < 0.0001; OR = 39.7), GFR 30-59 versus ≥60 mL/min/1.73 m (P = 0.0001; OR = 9.4), and clopidogrel loading dose >300 mg (P = 0.0001; OR = 8.9). Significant independent risk factors for minor bleeding after PCI were increased troponin I level (P = 0.0004; OR = 2.1), platelet glycoprotein IIb/IIIa inhibitors (P = 0.039; OR = 2.4), GFR 30-59 versus ≥60 mL/min/1.73 m (P < 0.0001; OR = 2.5), thrombolytics (P = 0.01; OR = 2.7), clopidogrel loading dose >300 mg (P < 0.0001; OR = 4.2), and systolic blood pressure during PCI (P < 0.0001; OR = 1.03 per mm Hg). In-hospital deaths included 5 of 34 patients (15%) with major bleeding, none of 253 patients (0%) with minor bleeding, and none of 347 patients (0%) with no bleeding (P < 0.0001). Hospital duration was 11.0 days in patients with major bleeding, 3.4 days in patients with minor bleeding, and 1.8 days in patients with no bleeding (P < 0.0001).

Original languageEnglish (US)
Pages (from-to)e74-e77
JournalAmerican Journal of Therapeutics
Volume17
Issue number4
DOIs
StatePublished - Jul 1 2010

Keywords

  • acute coronary syndromes
  • bleeding
  • glomerular filtration rate
  • percutaneous coronary intervention
  • troponin I

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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