TY - JOUR
T1 - RLIP76 and Cancer
AU - Awasthi, Sanjay
AU - Singhal, Sharad S.
AU - Awasthi, Yogesh C.
AU - Martin, Bryan
AU - Woo, Jung Hee
AU - Cunningham, C. Casey
AU - Frankel, Arthur E.
PY - 2008/7/15
Y1 - 2008/7/15
N2 - RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.
AB - RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.
UR - http://www.scopus.com/inward/record.url?scp=51649103801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51649103801&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-08-0145
DO - 10.1158/1078-0432.CCR-08-0145
M3 - Article
C2 - 18628450
AN - SCOPUS:51649103801
SN - 1078-0432
VL - 14
SP - 4372
EP - 4384
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 14
ER -