RLIP76 and Cancer

Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung Hee Woo, C. Casey Cunningham, Arthur E. Frankel

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.

Original languageEnglish (US)
Pages (from-to)4372-4384
Number of pages13
JournalClinical Cancer Research
Volume14
Issue number14
DOIs
StatePublished - Jul 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Awasthi, S., Singhal, S. S., Awasthi, Y. C., Martin, B., Woo, J. H., Cunningham, C. C., & Frankel, A. E. (2008). RLIP76 and Cancer. Clinical Cancer Research, 14(14), 4372-4384. https://doi.org/10.1158/1078-0432.CCR-08-0145