RLIP76 and Cancer

Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung Hee Woo, C. Casey Cunningham, Arthur E. Frankel

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.

Original languageEnglish (US)
Pages (from-to)4372-4384
Number of pages13
JournalClinical Cancer Research
Volume14
Issue number14
DOIs
StatePublished - Jul 15 2008

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Carcinoma
GTPase-Activating Proteins
Drug Therapy
Clathrin
Spindle Apparatus
Membrane Transport Proteins
Radiation Tolerance
Xenobiotics
Endocytosis
Cytosol
Poisoning
Glutathione
Melanoma
Neoplasms
Proteins
Cell Membrane
Lung
Antibodies
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Awasthi, S., Singhal, S. S., Awasthi, Y. C., Martin, B., Woo, J. H., Cunningham, C. C., & Frankel, A. E. (2008). RLIP76 and Cancer. Clinical Cancer Research, 14(14), 4372-4384. https://doi.org/10.1158/1078-0432.CCR-08-0145

RLIP76 and Cancer. / Awasthi, Sanjay; Singhal, Sharad S.; Awasthi, Yogesh C.; Martin, Bryan; Woo, Jung Hee; Cunningham, C. Casey; Frankel, Arthur E.

In: Clinical Cancer Research, Vol. 14, No. 14, 15.07.2008, p. 4372-4384.

Research output: Contribution to journalArticle

Awasthi, S, Singhal, SS, Awasthi, YC, Martin, B, Woo, JH, Cunningham, CC & Frankel, AE 2008, 'RLIP76 and Cancer', Clinical Cancer Research, vol. 14, no. 14, pp. 4372-4384. https://doi.org/10.1158/1078-0432.CCR-08-0145
Awasthi S, Singhal SS, Awasthi YC, Martin B, Woo JH, Cunningham CC et al. RLIP76 and Cancer. Clinical Cancer Research. 2008 Jul 15;14(14):4372-4384. https://doi.org/10.1158/1078-0432.CCR-08-0145
Awasthi, Sanjay ; Singhal, Sharad S. ; Awasthi, Yogesh C. ; Martin, Bryan ; Woo, Jung Hee ; Cunningham, C. Casey ; Frankel, Arthur E. / RLIP76 and Cancer. In: Clinical Cancer Research. 2008 ; Vol. 14, No. 14. pp. 4372-4384.
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