Rodent models of human narcolepsy-cataplexy

Takeshi Sakurai, Masashi Yanagisawa, Michihiro Mieda

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

7. Conclusions: Behavioral and electrophysiological analysis of orexin-/- mice, together with studies on narcoleptic OX2R-deficient dogs, made a big jump in our understanding on narcolepsy-cataplexy, as well as regulation of sleep/wake cycle. Mouse molecular genetics succeeded to dissect non-REM and REM sleep regulatory processes by comparing mutants of every component of the orexin signaling pathway. Furthermore, obesity in orexin/ataxin-3 transgenic and orexin-/- mice directed researchers' interest toward metabolic abnormalities in narcolepsy patients. One of big advantages of using rodent models is easiness to prepare large number of animals for systematic studies. Detailed analyses of mouse and rat models of narcolepsy described here would not only deepen our understanding of disturbances of sleep regulation in narcolepsy but might also find out novel aspects of physiological abnormalities in human narcolepsy patients.

Original languageEnglish (US)
Title of host publicationHypocretins
Subtitle of host publicationIntegrators of Physiological Functions
PublisherSpringer US
Pages27-38
Number of pages12
ISBN (Electronic)9780387254463
ISBN (Print)038725000X, 9780387250007
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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    Sakurai, T., Yanagisawa, M., & Mieda, M. (2005). Rodent models of human narcolepsy-cataplexy. In Hypocretins: Integrators of Physiological Functions (pp. 27-38). Springer US. https://doi.org/10.1007/0-387-25446-3_3