Role of dihydrotestosterone in androgen action

Jean D. Wilson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Androgen action differs from that of most hormones in that testosterone, the major androgen secreted from the testes and the most abundant androgen in the circulation of men, is not the principal androgen within target cells. Indeed, abundant evidence indicates that most androgen actions are mediated by the 5α-reduced metabolite dihydrotestosterone that is formed in target tissues. The conversion of testosterone to dihydrotestosterone is mediated by two isoenzymes; mutations in the steroid 5α-reductase 2 gene cause a rare autosomal-recessive form of male pseudohermaphroditism, and inhibition of this enzyme causes regression of the prostate gland. Dihydrotestosterone binds more tightly to the androgen receptor than does testosterone, but it is not clear whether this property is the sole explanation for its essential role in androgen action. Nor is it clear whether some androgenic effects may be mediated by circulating dihydrotestosterone acting as a hormone.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalProstate
Volume28
Issue number3 SUPPL. 6
StatePublished - Jan 1 1996

Keywords

  • benign prostatic hyperplasia
  • male pseudohermaphroditism
  • steroid 5α- reductase

ASJC Scopus subject areas

  • Oncology
  • Urology

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