Role of dihydrotestosterone in androgen action

Jean D. Wilson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Androgen action differs from that of most hormones in that testosterone, the major androgen secreted from the testes and the most abundant androgen in the circulation of men, is not the principal androgen within target cells. Indeed, abundant evidence indicates that most androgen actions are mediated by the 5α-reduced metabolite dihydrotestosterone that is formed in target tissues. The conversion of testosterone to dihydrotestosterone is mediated by two isoenzymes; mutations in the steroid 5α-reductase 2 gene cause a rare autosomal-recessive form of male pseudohermaphroditism, and inhibition of this enzyme causes regression of the prostate gland. Dihydrotestosterone binds more tightly to the androgen receptor than does testosterone, but it is not clear whether this property is the sole explanation for its essential role in androgen action. Nor is it clear whether some androgenic effects may be mediated by circulating dihydrotestosterone acting as a hormone.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalProstate
Volume28
Issue number3 SUPPL. 6
StatePublished - 1996

Fingerprint

Dihydrotestosterone
Androgens
Testosterone
XY Disorders of Sex Development 46
Hormones
Androgen Receptors
Isoenzymes
Testis
Prostate
Oxidoreductases
Steroids
Mutation
Enzymes
Genes

Keywords

  • benign prostatic hyperplasia
  • male pseudohermaphroditism
  • steroid 5α- reductase

ASJC Scopus subject areas

  • Urology

Cite this

Wilson, J. D. (1996). Role of dihydrotestosterone in androgen action. Prostate, 28(3 SUPPL. 6), 88-92.

Role of dihydrotestosterone in androgen action. / Wilson, Jean D.

In: Prostate, Vol. 28, No. 3 SUPPL. 6, 1996, p. 88-92.

Research output: Contribution to journalArticle

Wilson, JD 1996, 'Role of dihydrotestosterone in androgen action', Prostate, vol. 28, no. 3 SUPPL. 6, pp. 88-92.
Wilson JD. Role of dihydrotestosterone in androgen action. Prostate. 1996;28(3 SUPPL. 6):88-92.
Wilson, Jean D. / Role of dihydrotestosterone in androgen action. In: Prostate. 1996 ; Vol. 28, No. 3 SUPPL. 6. pp. 88-92.
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