Role of endothelin in the exercise intolerance of chronic heart failure

Henry Krum, Rochelle Goldsmith, Michelle Wilshire-Clement, Myron Miller, Milton Packer

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.

Original languageEnglish (US)
Pages (from-to)1284-1286
Number of pages3
JournalThe American Journal of Cardiology
Volume75
Issue number17
DOIs
StatePublished - Jun 15 1995

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Endothelins
Heart Failure
Exercise
Vasoconstrictor Agents
Endothelin-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Krum, H., Goldsmith, R., Wilshire-Clement, M., Miller, M., & Packer, M. (1995). Role of endothelin in the exercise intolerance of chronic heart failure. The American Journal of Cardiology, 75(17), 1284-1286. https://doi.org/10.1016/S0002-9149(99)80783-8

Role of endothelin in the exercise intolerance of chronic heart failure. / Krum, Henry; Goldsmith, Rochelle; Wilshire-Clement, Michelle; Miller, Myron; Packer, Milton.

In: The American Journal of Cardiology, Vol. 75, No. 17, 15.06.1995, p. 1284-1286.

Research output: Contribution to journalArticle

Krum, H, Goldsmith, R, Wilshire-Clement, M, Miller, M & Packer, M 1995, 'Role of endothelin in the exercise intolerance of chronic heart failure', The American Journal of Cardiology, vol. 75, no. 17, pp. 1284-1286. https://doi.org/10.1016/S0002-9149(99)80783-8
Krum, Henry ; Goldsmith, Rochelle ; Wilshire-Clement, Michelle ; Miller, Myron ; Packer, Milton. / Role of endothelin in the exercise intolerance of chronic heart failure. In: The American Journal of Cardiology. 1995 ; Vol. 75, No. 17. pp. 1284-1286.
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