Role of low-density lipoproteins in atherogenesis and development of coronary heart disease

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important-through down- regulation, defects in structure, or decreased numbers-as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalClinical chemistry
Volume41
Issue number1
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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