Abstract
There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important-through down- regulation, defects in structure, or decreased numbers-as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-146 |
| Number of pages | 8 |
| Journal | Clinical chemistry |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1995 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical