Role of low-density lipoproteins in atherogenesis and development of coronary heart disease

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important-through down- regulation, defects in structure, or decreased numbers-as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalClinical Chemistry
Volume41
Issue number1
StatePublished - 1995

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LDL Lipoproteins
Coronary Disease
Atherosclerosis
LDL Receptors
Apolipoproteins B
Nutrition
Hypercholesterolemia
Metabolism
Coronary Artery Disease
Blood
Down-Regulation
Aging of materials
Hormones
Diet
Defects

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Role of low-density lipoproteins in atherogenesis and development of coronary heart disease. / Grundy, Scott M.

In: Clinical Chemistry, Vol. 41, No. 1, 1995, p. 139-146.

Research output: Contribution to journalArticle

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