Role of neuropathy and high foot pressures in diabetic foot ulceration

Robert G. Frykberg, Lawrence A. Lavery, Hau Pham, Carolyn Harvey, Lawrence Harkless, Aristidis Veves

Research output: Contribution to journalArticle

298 Citations (Scopus)

Abstract

OBJECTIVE - High plantar foot pressures in association with peripheral neuropathy have been ascertained to be important risk factors for ulceration in the diabetic foot. Most studies investigating these parameters have been limited by their size and the homogeneity of study subjects. The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population. RESEARCH DESIGN AND METHODS - We studied a cross-sectional group 251 diabetic patients of Caucasian (group C) (n = 121), black (group B) (n = 36), and Hispanic (group H) (n = 94) racial origins with an overall age of 58.5 ± 12.5 years (range 20-83). There was an equal distribution of men and women across the entire study population. All patients underwent a complete medical history and lower extremity evaluation for neuropathy and foot pressures. Neuropathic parameters were dichotomized (0/1) into two high-risk variables: patients with a vibration perception threshold (VPT) ≤ 25 V were categorized as HiVPT (n = 132) and those with Semmes-Weinstein monofilament tests ≤ 5.07 were classified as HiSWF (n = 190). The mean dynamic foot pressures of three footsteps were measured using the F-scan mat system with patients walking without shoes. Maximum plantar pressures were dichotomized into a high-pressure variable (Pmax6) indicating those subjects with pressures ≤6 kg/cm2 (n = 96). A total of 99 patients had a current or prior history of ulceration at baseline. RESULTS - Joint mobility was significantly greater in the Hispanic cohort compared with the other groups at the first metatarsal-phalangeal joint (C 67 ± 23°, B 69 ± 23°, H 82 ± 23°, P = 0.000), while the subtalar joint mobility was reduced in the Caucasian group (C 21 ± 8°, B 26 ± 7°, H 27 ± 11°, P = 0.000). Maximum plantar foot pressures were significantly higher in the Caucasian group (C 6.7 ± 2.9 kg/cm2, B 5.7 ± 2.8 kg/cm2, H 4.4 ± 1.9 kg/cm2, P = 0.000). Univariate logistic regression for Pmax6 on the history of ulceration yielded as odds ratio (OR) of 3.9 (P = 0.000). For HiVPT, the OR was 11.7 (P = 0.000), and for HiSWF, the OR was 9.6 (P = 0.000). Controlling for age, diabetes duration, sex, and race (all P < 0.05), multivariate logistic regression yielded the following significant associations with ulceration: Pmax6 (OR = 2.1, P = 0.002), HiVPT (OR = 4.4, P = 0.000), and HiSWF (OR = 4.1, P = 0.000). CONCLUSIONS - We conclude that both high foot pressures (≤6 kg/cm2) and neuropathy are independently associated with ulceration in a diverse diabetic population, with the latter having the greater magnitude of effect. In black and Hispanic diabetic patients especially, joint mobility and plantar pressures are less predictive of ulceration than in Caucasians.

Original languageEnglish (US)
Pages (from-to)1714-1719
Number of pages6
JournalDiabetes Care
Volume21
Issue number10
DOIs
StatePublished - 1998

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Diabetic Foot
Foot
Pressure
Odds Ratio
Hispanic Americans
Joints
Peripheral Nervous System Diseases
Logistic Models
Subtalar Joint
Population
Metatarsal Bones
Shoes
Vibration
Walking
Lower Extremity
Research Design
History

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Frykberg, R. G., Lavery, L. A., Pham, H., Harvey, C., Harkless, L., & Veves, A. (1998). Role of neuropathy and high foot pressures in diabetic foot ulceration. Diabetes Care, 21(10), 1714-1719. https://doi.org/10.2337/diacare.21.10.1714

Role of neuropathy and high foot pressures in diabetic foot ulceration. / Frykberg, Robert G.; Lavery, Lawrence A.; Pham, Hau; Harvey, Carolyn; Harkless, Lawrence; Veves, Aristidis.

In: Diabetes Care, Vol. 21, No. 10, 1998, p. 1714-1719.

Research output: Contribution to journalArticle

Frykberg, RG, Lavery, LA, Pham, H, Harvey, C, Harkless, L & Veves, A 1998, 'Role of neuropathy and high foot pressures in diabetic foot ulceration', Diabetes Care, vol. 21, no. 10, pp. 1714-1719. https://doi.org/10.2337/diacare.21.10.1714
Frykberg, Robert G. ; Lavery, Lawrence A. ; Pham, Hau ; Harvey, Carolyn ; Harkless, Lawrence ; Veves, Aristidis. / Role of neuropathy and high foot pressures in diabetic foot ulceration. In: Diabetes Care. 1998 ; Vol. 21, No. 10. pp. 1714-1719.
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abstract = "OBJECTIVE - High plantar foot pressures in association with peripheral neuropathy have been ascertained to be important risk factors for ulceration in the diabetic foot. Most studies investigating these parameters have been limited by their size and the homogeneity of study subjects. The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population. RESEARCH DESIGN AND METHODS - We studied a cross-sectional group 251 diabetic patients of Caucasian (group C) (n = 121), black (group B) (n = 36), and Hispanic (group H) (n = 94) racial origins with an overall age of 58.5 ± 12.5 years (range 20-83). There was an equal distribution of men and women across the entire study population. All patients underwent a complete medical history and lower extremity evaluation for neuropathy and foot pressures. Neuropathic parameters were dichotomized (0/1) into two high-risk variables: patients with a vibration perception threshold (VPT) ≤ 25 V were categorized as HiVPT (n = 132) and those with Semmes-Weinstein monofilament tests ≤ 5.07 were classified as HiSWF (n = 190). The mean dynamic foot pressures of three footsteps were measured using the F-scan mat system with patients walking without shoes. Maximum plantar pressures were dichotomized into a high-pressure variable (Pmax6) indicating those subjects with pressures ≤6 kg/cm2 (n = 96). A total of 99 patients had a current or prior history of ulceration at baseline. RESULTS - Joint mobility was significantly greater in the Hispanic cohort compared with the other groups at the first metatarsal-phalangeal joint (C 67 ± 23°, B 69 ± 23°, H 82 ± 23°, P = 0.000), while the subtalar joint mobility was reduced in the Caucasian group (C 21 ± 8°, B 26 ± 7°, H 27 ± 11°, P = 0.000). Maximum plantar foot pressures were significantly higher in the Caucasian group (C 6.7 ± 2.9 kg/cm2, B 5.7 ± 2.8 kg/cm2, H 4.4 ± 1.9 kg/cm2, P = 0.000). Univariate logistic regression for Pmax6 on the history of ulceration yielded as odds ratio (OR) of 3.9 (P = 0.000). For HiVPT, the OR was 11.7 (P = 0.000), and for HiSWF, the OR was 9.6 (P = 0.000). Controlling for age, diabetes duration, sex, and race (all P < 0.05), multivariate logistic regression yielded the following significant associations with ulceration: Pmax6 (OR = 2.1, P = 0.002), HiVPT (OR = 4.4, P = 0.000), and HiSWF (OR = 4.1, P = 0.000). CONCLUSIONS - We conclude that both high foot pressures (≤6 kg/cm2) and neuropathy are independently associated with ulceration in a diverse diabetic population, with the latter having the greater magnitude of effect. In black and Hispanic diabetic patients especially, joint mobility and plantar pressures are less predictive of ulceration than in Caucasians.",
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TY - JOUR

T1 - Role of neuropathy and high foot pressures in diabetic foot ulceration

AU - Frykberg, Robert G.

AU - Lavery, Lawrence A.

AU - Pham, Hau

AU - Harvey, Carolyn

AU - Harkless, Lawrence

AU - Veves, Aristidis

PY - 1998

Y1 - 1998

N2 - OBJECTIVE - High plantar foot pressures in association with peripheral neuropathy have been ascertained to be important risk factors for ulceration in the diabetic foot. Most studies investigating these parameters have been limited by their size and the homogeneity of study subjects. The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population. RESEARCH DESIGN AND METHODS - We studied a cross-sectional group 251 diabetic patients of Caucasian (group C) (n = 121), black (group B) (n = 36), and Hispanic (group H) (n = 94) racial origins with an overall age of 58.5 ± 12.5 years (range 20-83). There was an equal distribution of men and women across the entire study population. All patients underwent a complete medical history and lower extremity evaluation for neuropathy and foot pressures. Neuropathic parameters were dichotomized (0/1) into two high-risk variables: patients with a vibration perception threshold (VPT) ≤ 25 V were categorized as HiVPT (n = 132) and those with Semmes-Weinstein monofilament tests ≤ 5.07 were classified as HiSWF (n = 190). The mean dynamic foot pressures of three footsteps were measured using the F-scan mat system with patients walking without shoes. Maximum plantar pressures were dichotomized into a high-pressure variable (Pmax6) indicating those subjects with pressures ≤6 kg/cm2 (n = 96). A total of 99 patients had a current or prior history of ulceration at baseline. RESULTS - Joint mobility was significantly greater in the Hispanic cohort compared with the other groups at the first metatarsal-phalangeal joint (C 67 ± 23°, B 69 ± 23°, H 82 ± 23°, P = 0.000), while the subtalar joint mobility was reduced in the Caucasian group (C 21 ± 8°, B 26 ± 7°, H 27 ± 11°, P = 0.000). Maximum plantar foot pressures were significantly higher in the Caucasian group (C 6.7 ± 2.9 kg/cm2, B 5.7 ± 2.8 kg/cm2, H 4.4 ± 1.9 kg/cm2, P = 0.000). Univariate logistic regression for Pmax6 on the history of ulceration yielded as odds ratio (OR) of 3.9 (P = 0.000). For HiVPT, the OR was 11.7 (P = 0.000), and for HiSWF, the OR was 9.6 (P = 0.000). Controlling for age, diabetes duration, sex, and race (all P < 0.05), multivariate logistic regression yielded the following significant associations with ulceration: Pmax6 (OR = 2.1, P = 0.002), HiVPT (OR = 4.4, P = 0.000), and HiSWF (OR = 4.1, P = 0.000). CONCLUSIONS - We conclude that both high foot pressures (≤6 kg/cm2) and neuropathy are independently associated with ulceration in a diverse diabetic population, with the latter having the greater magnitude of effect. In black and Hispanic diabetic patients especially, joint mobility and plantar pressures are less predictive of ulceration than in Caucasians.

AB - OBJECTIVE - High plantar foot pressures in association with peripheral neuropathy have been ascertained to be important risk factors for ulceration in the diabetic foot. Most studies investigating these parameters have been limited by their size and the homogeneity of study subjects. The objective of this study was therefore to ascertain the risk of ulceration associated with high foot pressures and peripheral neuropathy in a large and diverse diabetic population. RESEARCH DESIGN AND METHODS - We studied a cross-sectional group 251 diabetic patients of Caucasian (group C) (n = 121), black (group B) (n = 36), and Hispanic (group H) (n = 94) racial origins with an overall age of 58.5 ± 12.5 years (range 20-83). There was an equal distribution of men and women across the entire study population. All patients underwent a complete medical history and lower extremity evaluation for neuropathy and foot pressures. Neuropathic parameters were dichotomized (0/1) into two high-risk variables: patients with a vibration perception threshold (VPT) ≤ 25 V were categorized as HiVPT (n = 132) and those with Semmes-Weinstein monofilament tests ≤ 5.07 were classified as HiSWF (n = 190). The mean dynamic foot pressures of three footsteps were measured using the F-scan mat system with patients walking without shoes. Maximum plantar pressures were dichotomized into a high-pressure variable (Pmax6) indicating those subjects with pressures ≤6 kg/cm2 (n = 96). A total of 99 patients had a current or prior history of ulceration at baseline. RESULTS - Joint mobility was significantly greater in the Hispanic cohort compared with the other groups at the first metatarsal-phalangeal joint (C 67 ± 23°, B 69 ± 23°, H 82 ± 23°, P = 0.000), while the subtalar joint mobility was reduced in the Caucasian group (C 21 ± 8°, B 26 ± 7°, H 27 ± 11°, P = 0.000). Maximum plantar foot pressures were significantly higher in the Caucasian group (C 6.7 ± 2.9 kg/cm2, B 5.7 ± 2.8 kg/cm2, H 4.4 ± 1.9 kg/cm2, P = 0.000). Univariate logistic regression for Pmax6 on the history of ulceration yielded as odds ratio (OR) of 3.9 (P = 0.000). For HiVPT, the OR was 11.7 (P = 0.000), and for HiSWF, the OR was 9.6 (P = 0.000). Controlling for age, diabetes duration, sex, and race (all P < 0.05), multivariate logistic regression yielded the following significant associations with ulceration: Pmax6 (OR = 2.1, P = 0.002), HiVPT (OR = 4.4, P = 0.000), and HiSWF (OR = 4.1, P = 0.000). CONCLUSIONS - We conclude that both high foot pressures (≤6 kg/cm2) and neuropathy are independently associated with ulceration in a diverse diabetic population, with the latter having the greater magnitude of effect. In black and Hispanic diabetic patients especially, joint mobility and plantar pressures are less predictive of ulceration than in Caucasians.

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