Role of NKT cells in anterior chamber-associated immune deviation

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Cells in the eye have a limited capacity for regeneration and, as such, immune-mediated inflammation can lead to blindness. The eye is designed to quench immune-mediated inflammation - a condition known as immune privilege. An important component of immune privilege is the dynamic immunoregulatory process termed anterior chamber-associated immune deviation (ACAID), which is initiated when antigens enter the eye. ACAID suppresses the initiation of antigen-specific inflammation in the eye and the effector stages of immune reactions. Four organ systems are crucial for the induction of ACAID: the eye, thymus, spleen and sympathetic nervous system. Multiple cell populations contribute to ACAID, with natural killer T cells playing a crucial role in the thymic and splenic phases of ACAID. Interactions between natural killer T cells and multiple cell populations in the spleen culminate in the tight regulation of immune-mediated inflammation in the eye and the preservation of vision.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalExpert review of clinical immunology
Volume5
Issue number2
DOIs
StatePublished - Dec 1 2009

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Keywords

  • Anterior chamber
  • Anterior chamber-associated immune deviation
  • Corneal transplantation
  • Eye
  • Immune privilege
  • Natural killer T cell
  • T regulatory cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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