Role of the NLRP3 Inflammasome: Insights Into Cancer Hallmarks

Ting Yi Lin, Meng Chun Tsai, Wei Tu, Hsin Chih Yeh, Shu Chi Wang, Shu Pin Huang, Chia Yang Li

Research output: Contribution to journalReview articlepeer-review

Abstract

In response to a variety of stresses, mammalian cells activate the inflammasome for targeted caspase-dependent pyroptosis. The research community has recently begun to deduce that the activation of inflammasome is instigated by several known oncogenic stresses and metabolic perturbations; nevertheless, the role of inflammasomes in the context of cancer biology is less understood. In manipulating the expression of inflammasome, researchers have found that NLRP3 serves as a deterministic player in conducting tumor fate decisions. Understanding the mechanistic underpinning of pro-tumorigenic and anti-tumorigenic pathways might elucidate novel therapeutic onco-targets, thereby providing new opportunities to manipulate inflammasome in augmenting the anti-tumorigenic activity to prevent tumor expansion and achieve metastatic control. Accordingly, this review aims to decode the complexity of NLRP3, whereby summarizing and clustering findings into cancer hallmarks and tissue contexts may expedite consensus and underscore the potential of the inflammasome in drug translation.

Original languageEnglish (US)
Article number610492
JournalFrontiers in immunology
Volume11
DOIs
StatePublished - Feb 3 2021
Externally publishedYes

Keywords

  • NLRP3 inflammasome
  • cancer hallmarks
  • interleukin-1β
  • pyroptosis
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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