Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer

Linda A. Feagins

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut. (Inflamm Bowel Dis 2010)

Original languageEnglish (US)
Pages (from-to)1963-1968
Number of pages6
JournalInflammatory Bowel Diseases
Volume16
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Transforming Growth Factors
Colitis
Inflammatory Bowel Diseases
Colonic Neoplasms
Inflammation
Wound Healing
Embryonic Development
Gastrointestinal Tract
Cell Differentiation
Neoplasms
Growth

Keywords

  • cancer risk
  • carcinogenesis
  • chronic inflammation
  • inflammatory bowel disease
  • transforming growth factor-β

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer. / Feagins, Linda A.

In: Inflammatory Bowel Diseases, Vol. 16, No. 11, 11.2010, p. 1963-1968.

Research output: Contribution to journalArticle

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