Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer

Linda A. Feagins

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut. (Inflamm Bowel Dis 2010)

Original languageEnglish (US)
Pages (from-to)1963-1968
Number of pages6
JournalInflammatory bowel diseases
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2010

Keywords

  • cancer risk
  • carcinogenesis
  • chronic inflammation
  • inflammatory bowel disease
  • transforming growth factor-β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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