Roles of Active Site and Novel K⁺ Ion-binding Site Residues in Human Mitochondrial Branched-chain α-Ketoacid Decarboxylase/Dehydrogenase

Medicine & Life Sciences

• 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 100%
• Carboxy-Lyases 84%
• Thiamine Pyrophosphate 81%
• Catalytic Domain 56%
• Ions 51%
• Binding Sites 48%
• Maple Syrup Urine Disease 42%
• Enzymes 24%
• Mutation 15%
• Pseudomonas 9%
• Site-Directed Mutagenesis 9%
• Protons 9%
• Phosphates 7%
• Fluorescence 7%
• Oxygen 6%
• Amino Acids 6%

Chemical Compounds

• Thiamine 76%
• Mutation 26%
• Cofactor 19%
• Site-Directed Mutagenesis 10%
• Amino-Acid Residue 9%
• Amino Groups 8%
• Ion 8%
• Phosphate 6%
• Proton 6%
• Substitution Reaction 6%
• Fluorescence 5%
• Dioxygen 5%