Roles of FGF19 in liver metabolism

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Fibroblast growth factor 19 (FGF19) is an ileum-derived postprandial enterokine that governs bile acid and nutrient metabolism. Synthesis of FGF19 is up-regulated by bile acids and, conversely, bile acid synthesis is down-regulated by FGF19. FGF19 also controls gallbladder volume. FGF19 has been shown to have profound effects on glucose and lipid metabolism. Recent studies have described FGF19 as a postprandial regulator of hepatic glucose and protein metabolism. Like insulin, FGF19 induces protein and glycogen synthesis and suppresses gluconeogenesis in liver. However, unlike insulin, FGF19 does not stimulate lipogenesis. A key difference between FGF19 and insulin lies in their use of different cellular signaling pathways. The beneficial effects of FGF19 on liver metabolism raise the question of whether FGF19 and its variants can be used as therapeutic agents in the treatment of diabetes.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume76
DOIs
StatePublished - 2011

Fingerprint

Fibroblast Growth Factors
Metabolism
Liver
Bile Acids and Salts
Insulin
Cell signaling
Glucose
Lipogenesis
Gluconeogenesis
Medical problems
Gallbladder
Glycogen
Ileum
Lipid Metabolism
Nutrients
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Biochemistry

Cite this

Roles of FGF19 in liver metabolism. / Kir, S.; Kliewer, S. A.; Mangelsdorf, D. J.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 76, 2011, p. 139-144.

Research output: Contribution to journalArticle

@article{5f725faad29e44c5931539a358ca1ea1,
title = "Roles of FGF19 in liver metabolism",
abstract = "Fibroblast growth factor 19 (FGF19) is an ileum-derived postprandial enterokine that governs bile acid and nutrient metabolism. Synthesis of FGF19 is up-regulated by bile acids and, conversely, bile acid synthesis is down-regulated by FGF19. FGF19 also controls gallbladder volume. FGF19 has been shown to have profound effects on glucose and lipid metabolism. Recent studies have described FGF19 as a postprandial regulator of hepatic glucose and protein metabolism. Like insulin, FGF19 induces protein and glycogen synthesis and suppresses gluconeogenesis in liver. However, unlike insulin, FGF19 does not stimulate lipogenesis. A key difference between FGF19 and insulin lies in their use of different cellular signaling pathways. The beneficial effects of FGF19 on liver metabolism raise the question of whether FGF19 and its variants can be used as therapeutic agents in the treatment of diabetes.",
author = "S. Kir and Kliewer, {S. A.} and Mangelsdorf, {D. J.}",
year = "2011",
doi = "10.1101/sqb.2011.76.010710",
language = "English (US)",
volume = "76",
pages = "139--144",
journal = "Cold Spring Harbor Symposia on Quantitative Biology",
issn = "0091-7451",
publisher = "Cold Spring Harbor Laboratory Press",

}

TY - JOUR

T1 - Roles of FGF19 in liver metabolism

AU - Kir, S.

AU - Kliewer, S. A.

AU - Mangelsdorf, D. J.

PY - 2011

Y1 - 2011

N2 - Fibroblast growth factor 19 (FGF19) is an ileum-derived postprandial enterokine that governs bile acid and nutrient metabolism. Synthesis of FGF19 is up-regulated by bile acids and, conversely, bile acid synthesis is down-regulated by FGF19. FGF19 also controls gallbladder volume. FGF19 has been shown to have profound effects on glucose and lipid metabolism. Recent studies have described FGF19 as a postprandial regulator of hepatic glucose and protein metabolism. Like insulin, FGF19 induces protein and glycogen synthesis and suppresses gluconeogenesis in liver. However, unlike insulin, FGF19 does not stimulate lipogenesis. A key difference between FGF19 and insulin lies in their use of different cellular signaling pathways. The beneficial effects of FGF19 on liver metabolism raise the question of whether FGF19 and its variants can be used as therapeutic agents in the treatment of diabetes.

AB - Fibroblast growth factor 19 (FGF19) is an ileum-derived postprandial enterokine that governs bile acid and nutrient metabolism. Synthesis of FGF19 is up-regulated by bile acids and, conversely, bile acid synthesis is down-regulated by FGF19. FGF19 also controls gallbladder volume. FGF19 has been shown to have profound effects on glucose and lipid metabolism. Recent studies have described FGF19 as a postprandial regulator of hepatic glucose and protein metabolism. Like insulin, FGF19 induces protein and glycogen synthesis and suppresses gluconeogenesis in liver. However, unlike insulin, FGF19 does not stimulate lipogenesis. A key difference between FGF19 and insulin lies in their use of different cellular signaling pathways. The beneficial effects of FGF19 on liver metabolism raise the question of whether FGF19 and its variants can be used as therapeutic agents in the treatment of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84867433557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867433557&partnerID=8YFLogxK

U2 - 10.1101/sqb.2011.76.010710

DO - 10.1101/sqb.2011.76.010710

M3 - Article

C2 - 21813638

AN - SCOPUS:84867433557

VL - 76

SP - 139

EP - 144

JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

SN - 0091-7451

ER -