Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity

Research output: Contribution to journalReview article

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Abstract

Regulated intramembrane proteolysis (RIP) is a signaling mechanism through which transmembrane precursor proteins are cleaved to liberate their cytoplasmic and/or luminal/extracellular fragments from membranes so that these fragments are able to function at a new location. Recent studies have indicated that this proteolytic reaction plays an important role in host-virus interaction. On one hand, RIP transfers the signal from the endoplasmic reticulum (ER) to nucleus to activate antiviral genes in response to alteration of the ER caused by viral infection. On the other hand, RIP can be hijacked by virus to process transmembrane viral protein precursors and to destroy transmembrane antiviral proteins. Understanding this Yin and Yang side of RIP may lead to new strategies to combat viral infection. This article is part of a Special Issue entitled: Intramembrane Proteases.

Original languageEnglish (US)
Pages (from-to)2926-2932
Number of pages7
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1828
Issue number12
DOIs
StatePublished - Oct 14 2013

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Keywords

  • CREB3
  • CREB3L1
  • Regulated intramembrane proteolysis
  • Signal peptide-peptidase
  • Site-2 protease
  • Virus

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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