Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation

Fabian Rivera-Chávez, Sebastian E. Winter, Christopher A. Lopez, Mariana N. Xavier, Maria G. Winter, Sean Paul Nuccio, Joseph M. Russell, Richard C. Laughlin, Sara D. Lawhon, Torsten Sterzenbach, Charles L. Bevins, Renée M. Tsolis, Rasika Harshey, L. Garry Adams, Andreas J. Bäumler

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during inflammation remain unknown. Here we identify respiratory electron acceptors that are generated in the intestinal lumen as by-products of the host inflammatory response as in vivo signals for methyl-accepting chemotaxis proteins (MCPs). Three MCPs, including Trg, Tsr and Aer, enhanced the fitness of S. Typhimurium in a mouse colitis model. Aer mediated chemotaxis towards electron acceptors (energy taxis) in vitro and required tetrathionate respiration to confer a fitness advantage in vivo. Tsr mediated energy taxis towards nitrate but not towards tetrathionate in vitro and required nitrate respiration to confer a fitness advantage in vivo. These data suggest that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth.

Original languageEnglish (US)
Article numbere1003267
JournalPLoS pathogens
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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    Rivera-Chávez, F., Winter, S. E., Lopez, C. A., Xavier, M. N., Winter, M. G., Nuccio, S. P., Russell, J. M., Laughlin, R. C., Lawhon, S. D., Sterzenbach, T., Bevins, C. L., Tsolis, R. M., Harshey, R., Adams, L. G., & Bäumler, A. J. (2013). Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation. PLoS pathogens, 9(4), [e1003267]. https://doi.org/10.1371/journal.ppat.1003267