SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae

Wei Jong Shia, Bing Li, Jerry L. Workman

Research output: Contribution to journalArticle

79 Scopus citations


The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z have both previously been linked to an antisilencing function at the subtelomeric regions. SAS is an H4 Lys 16-specific histone acetyltransferase complex. Here we demonstrate that the H4 Lys 16 acetylation by SAS is required for efficient H2A.Z incorporation near telomeres. The presence of H4 Lys 16 acetylation and H2A.Z synergistically prevent the ectopic propagation of heterochromatin. Overall, our data suggest a novel antisilencing mechanism near telomeres.

Original languageEnglish (US)
Pages (from-to)2507-2512
Number of pages6
JournalGenes and Development
Issue number18
Publication statusPublished - Sep 15 2006



  • Antisilencing
  • H2A.Z
  • H4 Lys 16 acetylation
  • SAS

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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