Sciatic neurosteatosis: Relationship with age, gender, obesity and height

Shayna Ratner, Raamis Khwaja, Lihua Zhang, Yin Xi, Riham Dessouky, Craig Rubin, Avneesh Chhabra

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. Methods: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded. Inter-reader agreement was assessed using intra-class correlation coefficient (ICC). Spearman correlation coefficients were used for correlations with age, BMI and height and Wilcoxon rank sum test was used to assess gender differences. Results: A total of 67 patients were included in this study with male to female ratio of 1:1. Inter-reader agreement was good to excellent for FF measurements at both levels (ICC=0.71–0.90) and poor for sciatic nerve areas (ICC=0.08–0.27). Positive correlations of sciatic FF and area were seen with age (p value<0.05). Males had significantly higher sciatic intraneural fat than females (p<0.05). Conclusion: Fat quantification MRI is highly reproducible with significant positive correlations of sciatic FF and area with age, which may have implications for MRI diagnosis of sciatic neuropathy. Key Points: • MR proton density fat fraction is highly reproducible at multiple levels.• Sciatic intraneural fat is positively correlated with increasing age (p < 0.05).• Positive correlations exist between bilateral sciatic nerve areas and age (p < 0.05).• Males had significantly higher sciatic intraneural fat than females (p < 0.05).

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalEuropean Radiology
DOIs
StateAccepted/In press - Oct 23 2017

Fingerprint

Obesity
Fats
Sciatic Nerve
Nonparametric Statistics
Protons
Sciatic Neuropathy
Lumbosacral Plexus
Research Ethics Committees
Hand
Cross-Sectional Studies

Keywords

  • Fat quantification
  • MRI
  • Neuropathy
  • Neurosteatosis
  • Proton density fat fraction
  • Sciatic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Sciatic neurosteatosis : Relationship with age, gender, obesity and height. / Ratner, Shayna; Khwaja, Raamis; Zhang, Lihua; Xi, Yin; Dessouky, Riham; Rubin, Craig; Chhabra, Avneesh.

In: European Radiology, 23.10.2017, p. 1-8.

Research output: Contribution to journalArticle

Ratner, Shayna ; Khwaja, Raamis ; Zhang, Lihua ; Xi, Yin ; Dessouky, Riham ; Rubin, Craig ; Chhabra, Avneesh. / Sciatic neurosteatosis : Relationship with age, gender, obesity and height. In: European Radiology. 2017 ; pp. 1-8.
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abstract = "Aim: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. Methods: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded. Inter-reader agreement was assessed using intra-class correlation coefficient (ICC). Spearman correlation coefficients were used for correlations with age, BMI and height and Wilcoxon rank sum test was used to assess gender differences. Results: A total of 67 patients were included in this study with male to female ratio of 1:1. Inter-reader agreement was good to excellent for FF measurements at both levels (ICC=0.71–0.90) and poor for sciatic nerve areas (ICC=0.08–0.27). Positive correlations of sciatic FF and area were seen with age (p value<0.05). Males had significantly higher sciatic intraneural fat than females (p<0.05). Conclusion: Fat quantification MRI is highly reproducible with significant positive correlations of sciatic FF and area with age, which may have implications for MRI diagnosis of sciatic neuropathy. Key Points: • MR proton density fat fraction is highly reproducible at multiple levels.• Sciatic intraneural fat is positively correlated with increasing age (p < 0.05).• Positive correlations exist between bilateral sciatic nerve areas and age (p < 0.05).• Males had significantly higher sciatic intraneural fat than females (p < 0.05).",
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AU - Rubin, Craig

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N2 - Aim: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. Methods: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded. Inter-reader agreement was assessed using intra-class correlation coefficient (ICC). Spearman correlation coefficients were used for correlations with age, BMI and height and Wilcoxon rank sum test was used to assess gender differences. Results: A total of 67 patients were included in this study with male to female ratio of 1:1. Inter-reader agreement was good to excellent for FF measurements at both levels (ICC=0.71–0.90) and poor for sciatic nerve areas (ICC=0.08–0.27). Positive correlations of sciatic FF and area were seen with age (p value<0.05). Males had significantly higher sciatic intraneural fat than females (p<0.05). Conclusion: Fat quantification MRI is highly reproducible with significant positive correlations of sciatic FF and area with age, which may have implications for MRI diagnosis of sciatic neuropathy. Key Points: • MR proton density fat fraction is highly reproducible at multiple levels.• Sciatic intraneural fat is positively correlated with increasing age (p < 0.05).• Positive correlations exist between bilateral sciatic nerve areas and age (p < 0.05).• Males had significantly higher sciatic intraneural fat than females (p < 0.05).

AB - Aim: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. Methods: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded. Inter-reader agreement was assessed using intra-class correlation coefficient (ICC). Spearman correlation coefficients were used for correlations with age, BMI and height and Wilcoxon rank sum test was used to assess gender differences. Results: A total of 67 patients were included in this study with male to female ratio of 1:1. Inter-reader agreement was good to excellent for FF measurements at both levels (ICC=0.71–0.90) and poor for sciatic nerve areas (ICC=0.08–0.27). Positive correlations of sciatic FF and area were seen with age (p value<0.05). Males had significantly higher sciatic intraneural fat than females (p<0.05). Conclusion: Fat quantification MRI is highly reproducible with significant positive correlations of sciatic FF and area with age, which may have implications for MRI diagnosis of sciatic neuropathy. Key Points: • MR proton density fat fraction is highly reproducible at multiple levels.• Sciatic intraneural fat is positively correlated with increasing age (p < 0.05).• Positive correlations exist between bilateral sciatic nerve areas and age (p < 0.05).• Males had significantly higher sciatic intraneural fat than females (p < 0.05).

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KW - Proton density fat fraction

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