Sclerosing cholangitis. Anatomical distribution of obstructive lesions

J. L. Cameron, B. W. Gayler, H. Sanfey, F. Milligan, S. Kaufman, W. C. Maddrey, H. F. Herlong

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Abstract

The cholangiograms of 36 patients with sclerosing cholangitis were reviewed. The mean age of the patient group was 43 years, and the mean disease duration was 4.5 years. Seventeen of the patients had associated inflammatory bowel disease. The mean serum bilirubin was 6.8 mg/dl, the mean SGOT was 105 IU/L, the mean SGPT was 108 IU/L, and the mean serum alkaline phosphatase was 534 IU/L. The cholangiograms demonstrated involvement of the extrahepatic bile ducts in 33 patients, involvement of the hepatic duct bifurcation in 33 patients, and involvement of the intrahepatic bile ducts in 35 patients. The cholangiograms were graded as to the areas of the most severe obstructive involvement. In 24 patients the area of most severe involvement was the hepatic duct bifurcation. In eight additional patients the hepatic duct bifurcation, along with the extrahepatic ducts and/or the intrahepatic ducts, were felt to be the areas most severely affected. This predilection for severe obstructive disease at the hepatic duct bifurcation in sclerosing cholangitis held for both patients with and without inflammatory bowel disease. Thus, most patients with sclerosing cholangitis have cholangiographic evidence of diffuse extrahepatic and intrahepatic biliary tract disease, with the hepatic duct bifurcation being the area generally most severely affected.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalAnnals of Surgery
Volume200
Issue number1
StatePublished - 1984

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Sclerosing Cholangitis
Common Hepatic Duct
Patient Participation
Inflammatory Bowel Diseases
Biliary Tract Diseases
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Aspartate Aminotransferases
Serum
Alanine Transaminase
Bilirubin
Alkaline Phosphatase
Age Groups

ASJC Scopus subject areas

  • Surgery

Cite this

Cameron, J. L., Gayler, B. W., Sanfey, H., Milligan, F., Kaufman, S., Maddrey, W. C., & Herlong, H. F. (1984). Sclerosing cholangitis. Anatomical distribution of obstructive lesions. Annals of Surgery, 200(1), 54-60.

Sclerosing cholangitis. Anatomical distribution of obstructive lesions. / Cameron, J. L.; Gayler, B. W.; Sanfey, H.; Milligan, F.; Kaufman, S.; Maddrey, W. C.; Herlong, H. F.

In: Annals of Surgery, Vol. 200, No. 1, 1984, p. 54-60.

Research output: Contribution to journalArticle

Cameron, JL, Gayler, BW, Sanfey, H, Milligan, F, Kaufman, S, Maddrey, WC & Herlong, HF 1984, 'Sclerosing cholangitis. Anatomical distribution of obstructive lesions', Annals of Surgery, vol. 200, no. 1, pp. 54-60.
Cameron JL, Gayler BW, Sanfey H, Milligan F, Kaufman S, Maddrey WC et al. Sclerosing cholangitis. Anatomical distribution of obstructive lesions. Annals of Surgery. 1984;200(1):54-60.
Cameron, J. L. ; Gayler, B. W. ; Sanfey, H. ; Milligan, F. ; Kaufman, S. ; Maddrey, W. C. ; Herlong, H. F. / Sclerosing cholangitis. Anatomical distribution of obstructive lesions. In: Annals of Surgery. 1984 ; Vol. 200, No. 1. pp. 54-60.
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