Screening and Detection of Apoptosis

Sergio Huerta, Emily J. Goulet, Sara Huerta-Yepez, Edward H. Livingston

Research output: Contribution to journalReview article

164 Scopus citations

Abstract

Since programmed cell death was first described by the electron microscopic cellular changes demonstrating an organized form of cell death over 30 years ago, it has undergone a great deal of scrutiny as a potential target for several diseases including cancer. The techniques for the study of apoptosis have evolved accordingly. Methodologies for the study of apoptosis were examined by a MEDLINE search of the English-language literature and are summarized in this review. This review discusses the various ways to study apoptosis with specific assays, reagents, and molecules. The particular advantages and disadvantages of each method are reviewed.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalJournal of Surgical Research
Volume139
Issue number1
DOIs
StatePublished - May 1 2007

Keywords

  • AIF
  • Apaf-1
  • Bcl-2
  • caspases
  • death receptor pathway
  • proteosome

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Screening and Detection of Apoptosis'. Together they form a unique fingerprint.

  • Cite this

    Huerta, S., Goulet, E. J., Huerta-Yepez, S., & Livingston, E. H. (2007). Screening and Detection of Apoptosis. Journal of Surgical Research, 139(1), 143-156. https://doi.org/10.1016/j.jss.2006.07.034