Secreted protein kinases

Vincent S. Tagliabracci, Lorenzo A. Pinna, Jack E. Dixon

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate. Despite its identification as the first phosphoprotein, the responsible kinase has remained obscure. This conundrum was solved with the discovery of a novel family of atypical protein kinases that are secreted and appear to phosphorylate numerous extracellular proteins, including casein. Fam20C, the archetypical member, phosphorylates secreted proteins within Ser-x-Glu/pSer motifs. This discovery has solved a 130-year-old mystery and has shed light on several human disorders of biomineralization.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalTrends in Biochemical Sciences
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2013

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Protein Kinases
Caseins
Biomineralization
Proteins
Phosphoproteins
Phosphotransferases
Genes
Phosphates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Secreted protein kinases. / Tagliabracci, Vincent S.; Pinna, Lorenzo A.; Dixon, Jack E.

In: Trends in Biochemical Sciences, Vol. 38, No. 3, 01.03.2013, p. 121-130.

Research output: Contribution to journalReview article

Tagliabracci, Vincent S. ; Pinna, Lorenzo A. ; Dixon, Jack E. / Secreted protein kinases. In: Trends in Biochemical Sciences. 2013 ; Vol. 38, No. 3. pp. 121-130.
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