Secretion of hypothalamic dopamine into the hypophysial portal vasculature: An overview

J. C. Porter; M. J. Reymond; J. Arita; J. F. Sissom

doi:10.1016/S0076-6879(83)03043-8

Secretion of hypothalamic dopamine into the hypophysial portal vasculature: An overview

J. C. Porter, M. J. Reymond, J. Arita, J. F. Sissom

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

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Abstract

Neurosecretory substances released in the median eminence by hypothalamic cells diffuse into blood within capillaries of the median eminence, and are directly transported to the sinusoids of the pars distalis by way of the hypophysial portal veins. Several of these neurosecretory substances are known to affect the release of hormones by cells of the pars distalis. The studies on the release of hypothalamic dopamine into hypophysial portal blood pertain to dopamine in blood collected from all of the portal vessels after transection of the pituitary stalk. Such results are reflective of the concentration of dopamine in the mixture of blood from all the vessels of the stalk. The rate of release of dopamine by hypothalamic neurons into hypophysial portal blood is subject to modification by a variety of agents and conditions.

Original language	English (US)
Pages (from-to)	607-618
Number of pages	12
Journal	Methods in Enzymology
Volume	103
Issue number	C
DOIs	https://doi.org/10.1016/S0076-6879(83)03043-8
State	Published - Jan 1 1983

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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title = "Secretion of hypothalamic dopamine into the hypophysial portal vasculature: An overview",

abstract = "Neurosecretory substances released in the median eminence by hypothalamic cells diffuse into blood within capillaries of the median eminence, and are directly transported to the sinusoids of the pars distalis by way of the hypophysial portal veins. Several of these neurosecretory substances are known to affect the release of hormones by cells of the pars distalis. The studies on the release of hypothalamic dopamine into hypophysial portal blood pertain to dopamine in blood collected from all of the portal vessels after transection of the pituitary stalk. Such results are reflective of the concentration of dopamine in the mixture of blood from all the vessels of the stalk. The rate of release of dopamine by hypothalamic neurons into hypophysial portal blood is subject to modification by a variety of agents and conditions.",

author = "Porter, {J. C.} and Reymond, {M. J.} and J. Arita and Sissom, {J. F.}",

note = "Funding Information: The authors wish to thank Anita Crockett for editorial assistance. Funding to support the experiments reported in this chapter was provided in part by Grants AM01237 and AG00306 of the National Institutes of Health, Bethesda, Maryland.",

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AU - Reymond, M. J.

AU - Arita, J.

AU - Sissom, J. F.

N1 - Funding Information: The authors wish to thank Anita Crockett for editorial assistance. Funding to support the experiments reported in this chapter was provided in part by Grants AM01237 and AG00306 of the National Institutes of Health, Bethesda, Maryland.

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N2 - Neurosecretory substances released in the median eminence by hypothalamic cells diffuse into blood within capillaries of the median eminence, and are directly transported to the sinusoids of the pars distalis by way of the hypophysial portal veins. Several of these neurosecretory substances are known to affect the release of hormones by cells of the pars distalis. The studies on the release of hypothalamic dopamine into hypophysial portal blood pertain to dopamine in blood collected from all of the portal vessels after transection of the pituitary stalk. Such results are reflective of the concentration of dopamine in the mixture of blood from all the vessels of the stalk. The rate of release of dopamine by hypothalamic neurons into hypophysial portal blood is subject to modification by a variety of agents and conditions.

AB - Neurosecretory substances released in the median eminence by hypothalamic cells diffuse into blood within capillaries of the median eminence, and are directly transported to the sinusoids of the pars distalis by way of the hypophysial portal veins. Several of these neurosecretory substances are known to affect the release of hormones by cells of the pars distalis. The studies on the release of hypothalamic dopamine into hypophysial portal blood pertain to dopamine in blood collected from all of the portal vessels after transection of the pituitary stalk. Such results are reflective of the concentration of dopamine in the mixture of blood from all the vessels of the stalk. The rate of release of dopamine by hypothalamic neurons into hypophysial portal blood is subject to modification by a variety of agents and conditions.

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Secretion of hypothalamic dopamine into the hypophysial portal vasculature: An overview

Abstract

ASJC Scopus subject areas

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