Secretory diarrhea in mixed connective tissue disease

Dwain L Thiele, G. J. Krejs

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intractable diarrhea of 2 years' duration was evaluated in a patient with mixed connective bowel disease and dilatation of the proximal small bowel. Stool analysis revealed secretory diarrhea. Intestinal perfusion studies showed that the jejenum was secreting water and electrolytes. Chloride and bicarbonate secretion against an electrical gradient suggested active anion secretion. Absorption in the ileum was normal. No evidence for bacterial colonization of the small bowel, protein-losing enteropathy, or a hormonal cause of intestinal secretion could be found. This case report suggests that water and electrolyte secretion in dilated segments of small bowel may be another cause of diarrhea in cases of gastrointestinal involvement by systemic connective tissue disease.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume80
Issue number2
StatePublished - 1985

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Mixed Connective Tissue Disease
Diarrhea
Electrolytes
Protein-Losing Enteropathies
Intestinal Secretions
Connective Tissue Diseases
Water
Bicarbonates
Ileum
Anions
Chlorides
Dilatation
Perfusion

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Secretory diarrhea in mixed connective tissue disease. / Thiele, Dwain L; Krejs, G. J.

In: American Journal of Gastroenterology, Vol. 80, No. 2, 1985, p. 107-110.

Research output: Contribution to journalArticle

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