Seeing is believing: Dynamic changes in renal epithelial autophagy during injury and repair

Fangming Lin, Zhao Wang, Joseph A Hill

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Ischemic injury to the kidneys is a prevalent clinical problem, contributing importantly to chronic kidney disease. Yet, underlying molecular mechanisms are elusive. To address the possible role of autophagy, we engineered a novel strain of mice harboring a ubiquitously expressed CAG-RFP-EGFP-LC3 transgene. Using this tool, we examined the post-ischemic kidney and detailed the dynamics of renal tubular epithelial autophagy. In addition, we defined the role of MTOR in the resolution of autophagy during epithelial survival and kidney repair.

Original languageEnglish (US)
Pages (from-to)691-693
Number of pages3
JournalAutophagy
Volume10
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • Dymanics
  • Ischemic injury
  • Renal epithelial cells
  • Renal repair
  • Tandem fluorescence

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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