Seipin: harvesting fat and keeping adipocytes healthy

Monala Jayaprakash Rao, Joel M. Goodman

Research output: Contribution to journalReview articlepeer-review

Abstract

Seipin is a key protein in the assembly of cytoplasmic lipid droplets (cLDs) and their maintenance at endoplasmic reticulum (ER)–LD junctions; the absence of seipin results in generalized lipodystrophy. How seipin mediates LD dynamics and prevents lipodystrophy are not well understood. New evidence suggests that seipin attracts triglyceride monomers from the ER to sites of droplet formation. By contrast, seipin may not be directly involved in the assembly of nuclear LDs and may actually suppress their formation at a distance. Seipin promotes adipogenesis, but lipodystrophy may also involve postadipogenic effects. We hypothesize that among these are a cycle of runaway lipolysis and lipotoxicity caused by aberrant LDs, resulting in a depletion of fat stores and a failure of adipose and other cells to thrive.

Original languageEnglish (US)
Pages (from-to)912-923
Number of pages12
JournalTrends in Cell Biology
Volume31
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • adipogenesis
  • fatty acid
  • lipid droplet
  • lipodystrophy
  • seipin

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Seipin: harvesting fat and keeping adipocytes healthy'. Together they form a unique fingerprint.

Cite this