TY - JOUR
T1 - Self-organization of treadmilling filaments
AU - Doubrovinski, K.
AU - Kruse, K.
PY - 2007/11/29
Y1 - 2007/11/29
N2 - The cytoskeleton is an active network of polar filaments. The activity can lead to the polymerization of filaments at one end and depolymerization at the other. This phenomenon is called treadmilling and is essential for many cellular processes, in particular, the crawling of cells on a substrate. We develop a microscopic theoretical framework for describing systems of treadmilling filaments. We show that such systems can self-organize into structures observed in cell fragments, in particular, asters and moving spots.
AB - The cytoskeleton is an active network of polar filaments. The activity can lead to the polymerization of filaments at one end and depolymerization at the other. This phenomenon is called treadmilling and is essential for many cellular processes, in particular, the crawling of cells on a substrate. We develop a microscopic theoretical framework for describing systems of treadmilling filaments. We show that such systems can self-organize into structures observed in cell fragments, in particular, asters and moving spots.
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U2 - 10.1103/PhysRevLett.99.228104
DO - 10.1103/PhysRevLett.99.228104
M3 - Article
C2 - 18233333
AN - SCOPUS:36649033632
SN - 0031-9007
VL - 99
JO - Physical Review Letters
JF - Physical Review Letters
IS - 22
M1 - 228104
ER -