Sensitization of radioresistant prostate cancer cells by resveratrol isolated from arachis hypogaea stems

Yu An Chen, Hsiu Man Lien, Min Chuan Kao, U. Ging Lo, Li Chiung Lin, Chun Jung Lin, Sheau Jiun Chang, Chia Chang Chen, Jer Tsong Hsieh, Ho Lin, Chih Hsin Tang, Chih Ho Lai

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Resveratrol (RV, 3,4,5-trihydroxystilbene) is naturally produced by a wide variety of plants including grapes and peanuts (Arachis hypogaea). However, the yield of RV from peanut stem and its potential radiosensitizing effects in prostate cancer (PCa) have not been well investigated. In this study, we characterized RV in peanut stem extract (PSE) for the first time and showed that both RV and PSE dose-dependently induced cell death in DOC-2/DAB2 interactive protein (DAB2IP)-deficient PCa cells with the radioresistant phenotype. Furthermore, the combination of radiation with either RV or PSE induced the death of radioresistant PCa cells through delayed repair of radiation-induced DNA double-strand break (DSB) and prolonged G2/M arrest, which induced apoptosis. The administration of RV and PSE effectively enhanced radiation therapy in the shDAB2IP PCa xenograft mouse model. These results demonstrate the promising synergistic effect of RV and PSE combined with radiation in the treatment of radioresistant PCa.

Original languageEnglish (US)
Article numbere0169204
JournalPloS one
Volume12
Issue number1
DOIs
StatePublished - Jan 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Chen, Y. A., Lien, H. M., Kao, M. C., Lo, U. G., Lin, L. C., Lin, C. J., Chang, S. J., Chen, C. C., Hsieh, J. T., Lin, H., Tang, C. H., & Lai, C. H. (2017). Sensitization of radioresistant prostate cancer cells by resveratrol isolated from arachis hypogaea stems. PloS one, 12(1), [e0169204]. https://doi.org/10.1371/journal.pone.0169204