Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Jen Liou; Tobias Meyer

doi:10.1016/j.devcel.2013.07.012

Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Jen Liou, Tobias Meyer

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The endoplasmic reticulum (ER) Ca²⁺ sensor STIM1 recruits and activates the plasma membrane (PM) Ca²⁺ channel Orai1 at ER-PM junctions for store-operated Ca²⁺ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Developmental cell
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2013.07.012
State	Published - Jul 29 2013

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2013.07.012

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title = "Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions",

abstract = "The endoplasmic reticulum (ER) Ca2+ sensor STIM1 recruits and activates the plasma membrane (PM) Ca2+ channel Orai1 at ER-PM junctions for store-operated Ca2+ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.",

author = "Jen Liou and Tobias Meyer",

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day = "29",

doi = "10.1016/j.devcel.2013.07.012",

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AU - Liou, Jen

AU - Meyer, Tobias

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N2 - The endoplasmic reticulum (ER) Ca2+ sensor STIM1 recruits and activates the plasma membrane (PM) Ca2+ channel Orai1 at ER-PM junctions for store-operated Ca2+ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

AB - The endoplasmic reticulum (ER) Ca2+ sensor STIM1 recruits and activates the plasma membrane (PM) Ca2+ channel Orai1 at ER-PM junctions for store-operated Ca2+ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

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ER -

Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Abstract

ASJC Scopus subject areas

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