The endoplasmic reticulum (ER) Ca2+ sensor STIM1 recruits and activates the plasma membrane (PM) Ca2+ channel Orai1 at ER-PM junctions for store-operated Ca2+ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology